Publications by authors named "N Mangafas"
Estimation of the determinants for HIV late presentation using the traditional definition and molecular clock-inferred dates: Evidence that older age, heterosexual risk group and more recent diagnosis are prognostic factors.
HIV Med
December 2022
Article Synopsis
- HIV late presentation (LP) is on the rise in Europe, particularly in Greece, prompting an investigation into the characteristics and factors influencing LP, defined by the time between HIV infection and diagnosis.
- Analysis of data from 6166 people living with HIV in Greece from 1999-2015 revealed that older age, heterosexual transmission, and more recent diagnoses correlate with a higher risk of LP, while individuals who inject drugs tend to get diagnosed more quickly than other groups.
- The findings highlight the need for focused healthcare interventions for older adults and heterosexuals, who are increasingly at risk for LP as they represent a growing segment of new diagnoses in Greece.
Our aim was to estimate the date of the origin and the transmission rates of the major local clusters of subtypes A1 and B in Greece. Phylodynamic analyses were conducted in 14 subtype A1 and 31 subtype B clusters. The earliest dates of origin for subtypes A1 and B were in 1982.
View Article and Find Full Text PDFOur aim was to investigate the dispersal patterns and parameters associated with local molecular transmission clusters (MTCs) of subtypes A1 and B in Greece (predominant HIV-1 subtypes). The analysis focused on 1751 (28.4%) and 2575 (41.
View Article and Find Full Text PDFObjectives: Subtypes A1 and B are the most prevalent HIV-1 clades in Greece. Subtype A1 epidemic is highly monophyletic and corresponds to transmissions that occurred locally. Our aim in this molecular epidemiology analysis was to investigate the role of early treatment in preventing new HIV-1 transmissions.
View Article and Find Full Text PDFBackground: Vaccine-induced memory B-cell (MBC) subsets have distinct roles in the establishment of protective immunity; MBCs expressing nonswitched immunoglobulin M (IgM+ MBCs) replenish the MBC pool, whereas MBCs expressing isotype-switched immunoglobulin (sIg+ MBCs) differentiate into plasma cells upon antigen reencounter. We investigated immunogenicity and MBCs induced by combined 13-valent pneumococcal conjugate vaccine (PCV13) and 23-valent pneumococcal polysaccharide vaccine (PPV23) in human immunodeficiency virus (HIV)-infected adults.
Methods: Forty HIV-seropositive adults receiving ART with undetectable viral loads were enrolled.