Publications by authors named "N Manfredi"

Background: Interleukin-6 (IL-6) represents one of the main molecules involved in inflammatory responses, which can be altered in either patients with cognitive impairment or obstructive sleep apnea (OSA). The present study aimed to evaluate serum IL-6 levels and cognitive performance in patients with severe OSA (Apnea-Hypopnea Index - AHI >30/h).

Methods: Thirty patients with severe OSA were compared to 15 controls similar in age, sex, and Body Mass Index.

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The rapid proliferation of internet-connected devices has transformed our daily habits prompting a shift towards greater sustainability in renewable energy for indoor applications. Among the various technologies available for obtaining energy in indoor conditions, Dye-Sensitized Solar Cells (DSSCs) stand out as the most promising due to their ability to efficiently convert ambient light into usable electricity. This study explores how the optimal matching of the UV-Vis absorption spectra of dyes commonly used in DSSCs with the emission profiles of indoor lamps allows for the enhanced efficiency of DSSC under indoor lighting.

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Bioactive films composed of Spiro-OMeTAD, a conductive molecular material (CMM), in combination with collagen have been manufactured and characterised for the first time. In-vitro cellular testing demonstrated the non-cytotoxicity of the doped Spiro-OMeTAD /Collagen films, opening the way for implantable or wearable medical devices and biosensors based on molecular materials.

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Decades of neuroimaging studies have shown modest differences in brain structure and connectivity in depression, hindering mechanistic insights or the identification of risk factors for disease onset. Furthermore, whereas depression is episodic, few longitudinal neuroimaging studies exist, limiting understanding of mechanisms that drive mood-state transitions. The emerging field of precision functional mapping has used densely sampled longitudinal neuroimaging data to show behaviourally meaningful differences in brain network topography and connectivity between and in healthy individuals, but this approach has not been applied in depression.

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Article Synopsis
  • Sleep problems are common in Parkinson's disease (PD) and can seriously impact patients' quality of life, with the study focusing on the effects of monoamine oxidase-B inhibitors (MAOB-Is) on these disturbances.
  • In a study of 45 PD patients with sleep issues, treatment with rasagiline and safinamide over four months showed improvements in motor function, with safinamide leading to better sleep quality and reduced movement disturbances.
  • Safinamide not only alleviated motor symptoms but also improved both subjective and objective sleep measures, suggesting its dual action on the brain may benefit sleep health in PD patients.
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