Publications by authors named "N Manel"
Lysosomes have a central role in the disposal of extracellular and intracellular cargo and also function as metabolic sensors and signalling platforms in the immunometabolic reprogramming of macrophages and other immune cells in atherosclerosis. Lysosomes can rapidly sense the presence of nutrients within immune cells, thereby switching from catabolism of extracellular material to the recycling of intracellular cargo. Such a fine-tuned degradative response supports the generation of metabolic building blocks through effectors such as mTORC1 or TFEB.
View Article and Find Full Text PDFImmune cells experience large cell shape changes during environmental patrolling because of the physical constraints that they encounter while migrating through tissues. These cells can adapt to such deformation events using dedicated shape-sensing pathways. However, how shape sensing affects immune cell function is mostly unknown.
View Article and Find Full Text PDFArticle Synopsis
- Age-related microangiopathy (SVD) damages small blood vessels leading to problems in the brain, retina, liver, and kidneys, and is linked to DNA damage as part of the aging process.
- Variants of the TREX1 protein, which play a crucial role in DNA repair, are associated with retinal vasculopathy with cerebral leukoencephalopathy (RVCL), causing improper localization within cells and potential DNA damage.
- Research shows that these TREX1 variants increase vulnerability to DNA damage and are connected to early-onset breast cancer, highlighting a link between abnormal TREX1 activity, aging-related DNA damage, and microvascular disease.
Article Synopsis
- Aging can weaken the immune system and make us more likely to get sick.
- Researchers found that a protein called Lamin A/C helps protect special immune cells in the lungs from damage as we age.
- Without Lamin A/C, these immune cells can get hurt, making us more vulnerable to illnesses like the flu and lung cancer.