Publications by authors named "N Maneekarn"

Article Synopsis
  • A study analyzed 1,625 stool samples from children with diarrhea in Japan over four years (2018-2022) to detect human astroviruses (HAstVs) and other diarrheal viruses, finding HAstV in 8.6% of samples.
  • The prevalence of HAstVs varied by year, with a notable increase to 20.1% in 2021-2022, and a significant infection rate was observed in children aged 1-3 years.
  • The study identified multiple HAstV genotypes, including outbreaks of HAstV1 and MLB2 during the COVID-19 pandemic, and noted for the first time a mixed infection of HAstV1 and MLB1.
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Coxsackievirus A2 (CVA2), a member of enterovirus A species (EV-A), is associated with diverse human diseases and occasionally causes acute gastroenteritis (AGE). In Thailand, CVA2 emerged as the predominant genotype in 2019. The increasing incidence of CVA2, coupled with the limited availability of full-length genomes, highlights the need for more complete genome sequence analysis to facilitate molecular epidemiology study.

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Article Synopsis
  • Viral enteric infections, caused by norovirus, rotavirus A, and human adenovirus, significantly impact the gastrointestinal system, highlighting the need for rapid diagnostic tools like the immunochromatographic (IC) test.
  • The IP-Triple I IC test kit was evaluated against known positive stool specimens and showed 100% specificity for detecting NoV, RVA, and HAdV, with varying sensitivity levels of 86.7% for RVA, 70.6% for NoV, and 76.2% for HAdV.
  • The findings confirm that the IP-Triple I IC test kit is effective for quick detection of multiple viral genotypes in stool samples, proving valuable for timely diagnosis during outbreaks.
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Article Synopsis
  • Rotavirus A (RVA) is the leading cause of gastroenteritis in kids under five, with unique bat-like strains identified in Northern Thailand in 2005 and 2019.* -
  • Genome sequencing and analysis showed that these strains have genetic similarities to bat RVA strains, indicating they may originate from bats but infect humans.* -
  • The study highlights the importance of monitoring RVA in both humans and animals to understand their evolution and the potential for transmission between species.*
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Enteroviruses (EVs) are well-known causes of a wide range of infectious diseases in infants and young children, ranging from mild illnesses to severe conditions, depending on the virus genotypes and the host's immunity. Recent advances in molecular surveillance and genotyping tools have identified over 116 different human EV genotypes from various types of clinical samples. However, the current knowledge about most of these genotypes, except for those of well-known genotypes like EV-A71 and EV-D68, is still limited due to a lack of comprehensive EV surveillance systems.

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