Publications by authors named "N Maloney"
Chronic ulcer in a patient with essential thrombocythemia taking hydroxyurea.
Dermatol Online J
June 2024
Article Synopsis
- Sometimes, skin ulcers that look like a disease called pyoderma gangrenosum might actually be caused by something else.
- Doctors need to carefully examine the skin and look for important signs, like a feature called atrophie blanche, to make sure they get the diagnosis right.
- If they don't recognize these signs, patients could end up getting strong medications that are not needed.
Purpose: Merkel cell carcinoma (MCC) is an aggressive skin cancer with a 40% recurrence rate, lacking effective prognostic biomarkers and surveillance methods. This prospective, multicenter, observational study aimed to evaluate circulating tumor DNA (ctDNA) as a biomarker for detecting MCC recurrence.
Methods: Plasma samples, clinical data, and imaging results were collected from 319 patients.
Background: Perivascular epithelioid cell tumours (PEComas) are rare soft tissue neoplasms that commonly occur in the uterus, skin, and liver and less commonly in the retroperitoneum, colon, and mediastinum.
Case Summary: A 36-year-old male patient with a history of mediastinal PEComa status post resection, essential hypertension, and atrial fibrillation status post appendage ligation currently not on anticoagulation presented with a 1-week history of fevers, chills, productive cough, chest pain, dyspnoea on exertion, loss of appetite, and general weakness. Vital signs, physical exam, laboratory data, electrocardiogram, and chest radiograph were grossly unremarkable.
Article Synopsis
- The study investigates the risk of developing subsequent primary cancers in patients diagnosed with cutaneous Merkel cell carcinoma (MCC), highlighting that this risk has not been thoroughly established before.
- Analyzing data from 17 registries from 2000 to 2019, researchers found that out of 6,146 patients diagnosed with MCC, 725 (11.8%) went on to develop other primary cancers.
- The results showed an overall increased risk of 28% for subsequent cancers, particularly for cutaneous melanoma, papillary thyroid carcinoma, and non-Hodgkin lymphoma, indicating that patients with MCC should be monitored closely for these additional health risks.