Fire blight cases in Almaty Region of Kazakhstan in the proximity of wild apple distribution area.

Fire blight caused by reached Kazakhstan in 2008. Here, the disease poses a threat not only to agricultural production of apples and pears, but also to the forests of wild , the progenitor of most domesticated apple varieties worldwide. In the period 2019-2021, the spread of fire blight in the growth area of wild apples was limited by the weather conditions.

[Clinical significance of serum levels of osteoproteherin and sclerostin in assessment of vascular calcification in chronic kidney disease stage 3-5].

Aim: To clarify the mechanisms of the effect of osteoprotegerin (OPG) and sclerostin on vascular calcification and the state of the cardiovascular system in chronic kidney disease (CKD).

Materials And Methods: A total of 110 patients aged 18 to 65 years with CKD stages 35D were examined. OPG, sclerostin, intact parathyroid hormone, and serum troponin I were determined using the commercial "Enzyme-linked Immunosorbent Assay Kit for Sclerostin" from Cloude-Clone Corp.

Bismuth-coated screen-printed electrodes for the simple voltammetric determination of formaldehyde.

For the first time, bismuth modified electrodes have been used for the voltammetric detection of formaldehyde (FM). The well-known method of forming formaldehyde hydrazone (FAH) in the presence of hydrazine sulphate was used to convert the hydrated form of FM into its electrochemically active derivative. Various experimental conditions for differential pulse voltammetry were studied to achieve the best analytical performance.

A positive experience in applying the biolistic approach to potato varieties Aksor and Nevskiy.

The method of biological ballistics (biolistic transformation, genetic bombardment) of plants is one of the most modern methods used for direct gene transfer into plant cells. The main advantages of this method include the ability to simultaneously incorporate several target genes into the plant genome, carry out transfer without unnecessary agrobacterial parts and plasmid DNA sequences, and the short time needed to produce transgenic cells. For different plant objects, the efficiency of obtaining transgenic plants by the ballistic method varies from 1 to 3 %.

Comparative Analysis of Cytotoxic Activity of New Nitrosyl Iron-Sulfur Complexes in Human Tumor Cells In Vitro.

We studied cytotoxic activity of new tetranitrosyl NO-generating binuclear iron-sulfur [Fe-S] complexes containing different ligands in the molecule against tumor cells in vitro. Cytotoxic activity of the most active complex with cysteamine (CysAm) was compared with that of antitumor drug cisplatin. Caspase activation and morphological changes in cells were visualized by fluorescence microscopy.