Publications by authors named "N Mahindroo"
Article Synopsis
- The study investigates dual inhibitors of falcipains FP-2 and FP-3, which show potential toxicity due to similar binding affinities with human cathepsins.
- Researchers aim to enhance the selectivity of these inhibitors by designing new analogs that interact better with falcipains and less with human cathepsins.
- Molecular dynamics simulations reveal that the newly designed analogs exhibit improved binding affinities and selectivity towards falcipains, reducing the risk of toxicity.
Article Synopsis
- Malaria, caused by Plasmodium species, poses a serious health threat in tropical regions, with increasing resistance to existing treatments prompting the need for new drug development.
- Falcipains, a group of cysteine proteases that play a key role in the parasite's heme metabolism during its life cycle in red blood cells, have been identified as promising targets for new therapies.
- This discussion reviews the biology and chemistry of falcipains, highlighting efforts to create effective inhibitors and examining why some compounds succeed while others fail in targeting these important proteins for antimalarial treatment.
The pandemic situation of COVID-19 has caused global alarm in health care, devastating loss of lives, strangled economy, and paralysis of normal livelihood. The high inter-individual transmission rate created havoc in the global community. Although tremendous efforts are pitching in from across the globe to understand this disease, the clinical features seemed to have a wide range including fever, cough, and fatigue are the prominent features.
View Article and Find Full Text PDFSolid cancers are one of the leading causes of cancer related deaths, characterized by rapid growth of tumour, and local and distant metastases. Current advances on multimodality care have substantially improved local control and metastasis-free survival of patients by resection of primary tumour. The major concern in disease prognosis is the timely detection of resectable or metastatic tumour, thus reinforcing the need for identification of biomarkers for premalignant lesions of solid cancer.
View Article and Find Full Text PDFDiscovery of robust, selective and specific biomarkers are important for early diagnosis and monitor progression of human diseases. Eye being a common target for several human diseases, vision impediment and complications are often associated with systemic and ocular diseases. Tears are bodily fluids that are closest to eye and are rich in protein content and other metabolites.
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