Publications by authors named "N Mahadevan"
Basal cell carcinomas (BCC) are driven primarily by cumulative ultraviolet (UV) radiation exposure resulting in activation of the Hedgehog (Hh) signaling pathway, often as a result of UV-mediated Patched-1 (PTCH1) gene inactivation. Accordingly, BCCs most commonly arise at sun-exposed sites such as the head and neck. Very rarely, BCCs can arise at sun-protected sites such as the genital skin and perianal area.
View Article and Find Full Text PDFDaily online adaptive radiotherapy (OART) is useful in radiotherapy of prostate cancer to reduce doses to the rectum and bladder which pose a challenge because of daily variation in shape and size. It also helps to reduce target margins while still maintaining target coverage. We present a case of prostate cancer resistant to androgen deprivation therapy and systemic therapy which was difficult to treat with definitive radiotherapy because of the unusual anatomical shape of the tumor impinging into the rectum.
View Article and Find Full Text PDFArticle Synopsis
- Undifferentiated melanoma lacks typical characteristics of conventional melanoma, making diagnosis challenging, but molecular studies have revealed some genetic alterations associated with it.
- Among 14 undifferentiated melanoma cases, a significant 57% had NRAS as a driver mutation, while 43% showed RAC1 mutations, which aren't as common in conventional melanoma.
- These findings suggest that traditional diagnostic methods like NRAS Q61R immunohistochemistry may not be reliable for undifferentiated melanoma, and RAC1 mutations could contribute to resistance against treatments targeting the MAPK pathway.
Background: Papillary renal neoplasm with reverse polarity is a recently recognized low-grade neoplasm with a favorable prognosis. To date, its cytologic features have not been well documented.
Methods: Two patients with papillary renal neoplasm with reverse polarity sampled by fine needle aspiration and core needle biopsy are described, one of whom is under active surveillance without clinical progression and the other is alive and well 16 years after partial nephrectomy.
Article Synopsis
- - Small-cell lung cancer (SCLC) is a highly lethal form of lung cancer that initially responds well to chemotherapy but becomes resistant at relapse.
- - The study found that the expression of the TREX1 gene is significantly increased in chemoresistant SCLC, indicating its role in the tumor's survival.
- - Inhibiting TREX1 may activate the immune response and make resistant SCLC cells more sensitive to chemotherapy, suggesting it could be a novel therapeutic target for improving treatment outcomes.