Publications by authors named "N Magula"
SARS-CoV-2 clearance requires adaptive immunity but the contribution of neutralizing antibodies and T cells in different immune states is unclear. Here we ask which adaptive immune responses associate with clearance of long-term SARS-CoV-2 infection in HIV-mediated immunosuppression after suppressive antiretroviral therapy (ART) initiation. We assembled a cohort of SARS-CoV-2 infected people in South Africa (n = 994) including participants with advanced HIV disease characterized by immunosuppression due to T cell depletion.
View Article and Find Full Text PDFAssessing index CD4 and associated outcomes at 1-year in a tertiary HIV clinic, KwaZulu-Natal.
S Afr Fam Pract (2004)
January 2024
Background: Human immunodeficiency virus (HIV) management guidelines have evolved from initiating therapy at CD4 counts of ≤ 200 cells/m3 to implementing universal test and treat (UTT). This study aimed to assess whether in clinical practice, patients are presenting with higher baseline CD4 counts, describe the incidence of opportunistic infections and the proportion that achieved viral suppression.
Methods: A retrospective cohort design with convenience sampling was conducted.
Article Synopsis
- The study aimed to identify risk factors for death in hospitalized COVID-19 patients in Africa, with a focus on South Africa as the most affected country.
- A systematic review followed PRISMA guidelines was conducted, analyzing 16 relevant articles out of 16,600 initially obtained from various databases, leading to pooled estimates of mortality and risk factors.
- Results showed a 13.9% mortality rate in hospitalized patients, with significant risk factors including advanced age, male gender, diabetes, hypertension, chronic kidney disease, and severe or critical illness conditions.
Background: Hypertension is the primary risk factor for stroke and heart disease, which are leading causes of death in South Africa. Despite the availability of treatments, there is an implementation gap in how best to deliver hypertension care in this resource-limited region.
Methods: We describe a three-arm parallel group individually randomized control trial to evaluate the effectiveness and implementation of a technology-supported, community-based intervention to improve blood pressure control among people with hypertension in rural KwaZulu-Natal.