Publications by authors named "N Madeira"
: Observational studies with data from real-world clinical practice with patients with difficult-to-treat depression (DTD) are rare. This study aims to collect observational data from the real-world clinical practice of a Portuguese community mental health team (CMHT) on the prevalence of DTD and to explore differences between DTD and non-DTD groups. : We conducted a retrospective chart review study using data from Electronic Health Records (EHRs) of adult patients with psychiatric disorders followed by a CMHT from the Department of Psychiatry of the Coimbra Local Health Unit (between 1 December 2020-31 December 2022).
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- Diagnosing psychotic disorders lacks sufficient molecular support, despite various research efforts focusing on different aspects of these conditions.
- The study utilized SWATH-MS proteomics on blood samples from first-episode psychosis patients and controls, identifying 389 proteins significant for distinguishing between the two groups.
- The findings emphasize the value of combining protein- and peptide-level analyses to uncover potential biomarkers for early detection of conditions like schizophrenia, suggesting that post-translational modifications of proteins may provide essential diagnostic insights.
Article Synopsis
- Autism is a common condition influenced by both single gene issues and multiple genes, and many autistic people need better healthcare that genomics can help provide.
- The European Autism GEnomics Registry (EAGER) aims to collect info about autistic people who have had their entire DNA sequenced to help with future research and trials.
- EAGER will involve 1,500 participants from 13 places in 8 countries who will share genetic samples and fill out surveys to help researchers understand the link between genetics and health.
Introduction: School feeding programs are important for ensuring food security and promoting child health and development, particularly in low-income countries. In view of this importance, it is possible to increase the quality of these meals by diversifying the vegetables offered and incorporating underutilized plants to improve dietary diversity and nutritional quality into school meals.
Methods: This study was carried out using the action research methodology following the implementation and development of the "Inova na Horta" project in the city of Jundiaí, São Paulo, Brazil.