Implications of recently derived thermodynamic data and specific ionic interaction theory parameters for (Mg/Ca)UO(CO) complexes on the predominance of the Mg-Ca-UO-OH-CO systems, and application to natural and legacy-mine waters.

The formation of alkaline earth(II)triscarbonatouranyl(VI) (AeUO(CO)) species that have been evidenced both in laboratory and in-field studies, is important from slightly acidic pH up to near degraded cementitious in carbonated waters. They are also showing distinctive luminescence properties with a hypsochromic shift relative to UO. The conditions of pH, activities of alkaline earth(II) free ions (mostly Mg and Ca) and carbonate ions (HCO) can be predicted from the thermodynamic functions and constants.

Radiolysis effect on Eu(III)-superplasticiser interactions in artificial cement and squeezed cement pore waters.

In the framework of the French deep geological repository for radioactive waste, cement-based materials are envisaged to immobilize radionuclides and/or provide protection from radiation to the environment. Superplasticisers (SPs) are added to these materials to increase their workability. SPs will undergo degradation by coupled radiolytic and hydrolytic effects in the pore solution leading to the formation of potentially complexing degradation products.

Drug-Disease Interaction and Time-Dependent Population Pharmacokinetics of Isatuximab in Relapsed/Refractory Multiple Myeloma Patients.

Isatuximab, a monoclonal antibody (mAb) of immunoglobulin G (IgG) isotype, specifically targets the cluster of differentiation 38 antigen overexpressed in malignant plasma cells. Isatuximab is used to treat multiple myeloma (MM), characterized by the excessive production of abnormal "myeloma proteins" (M-proteins) that may interact with therapeutic IgG mAb on the neonatal Fc receptor (FcRn)-mediated recycling pathway. The clinical pharmacology profile of isatuximab was investigated by population pharmacokinetics (PKs) modeling in 476 patients with MM who received 1-20 mg/kg isatuximab either as single agent or in combination with pomalidomide-dexamethasone in 4 clinical trials.

Multifractal Scalings Across the Many-Body Localization Transition.

In contrast with Anderson localization where a genuine localization is observed in real space, the many-body localization (MBL) problem is much less understood in Hilbert space, the support of the eigenstates. In this Letter, using exact diagonalization techniques we address the ergodicity properties in the underlying N-dimensional complex networks spanned by various computational bases for up to L=24 spin-1/2 particles (i.e.

How mobile is tritiated water through unsaturated cement-based materials? New insights from two complementary approaches.

This work presents two complementary approaches (for low and high desaturation) to study tritiated water (HTO) diffusion through unsaturated cement-based materials. The first approach was based on through-diffusion experiments where suction was controlled by osmosis. In the second approach, diffusion experiments were performed in humidity chambers controlled by under-saturated saline solutions.