Publications by authors named "N MANGAKIS"

The histological and histochemical findings and the clinical course of 160 cases of breast cancer were compared with the biochemical values of the content and pattern of glycosaminoglycans (GAG) in the tumour tissue. For this purpose the cases were divided into 4 groups of increasing malignancy of the tumours, based on the morphological data and the clinical course after radical mastectomy (4-9 years follow-up). Samples of tumour tissue were examined biochemically-analytically for their total content of glycosaminoglycans and for their mg/g values of hyaluronic acid (H), chondroitin-4- and chondroitin-6-sulphates (CA + CC), dermatan sulphate (CB), heparan sulphate (HpS) and component (K).

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Out of 400 surgical specimens besides the histological and histochemical tests the content of glycosaminoglycans (GAG) was determined using biochemical methods. There were involved different kinds of tumours (carcinoma of the breast and their metastases, mammary fibroadenom, sarcomata of different origin, malignant melanoma) as well as gynaecomastia and mastopathy. As the results demonstrate, growing tumours are characterized by an elevated content of GAG compared to their tissue of origin.

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