Fibrin Sealant TISSEEL Lyo as a haemostatic agent in vascular surgery: Results of randomized, controlled, patient-blinded, multicentre clinical study in the Russian population.

Background: This phase III, controlled, patient-blinded, multicentre study in two parallel, equal-sized treatment groups compared the efficacy and safety of TISSEEL Lyo, fibrin sealant versus Manual Compression (MC) with surgical gauze pads for use as a haemostatic agent in patients who underwent vascular surgery in Russia.

Methods: Adult patients, both genders, who received peripheral vascular expanded polytetrafluoroethylene conduits and had suture line bleeding after surgical haemostasis were enrolled. Patients were randomized to be treated with TISSEEL Lyo or MC.

Determination of the critical values of flow parameters characteristic of the alignment of cylindrical nano-objects in suspensions.

A method for determining the critical values of the flow speed and the flow constriction degree characteristic of the alignment of cylindrical nano-objects in a flowing suspension is proposed. Previously, the alignment process of cylindrical nano-objects in suspensions was investigated by using birefringence of the polarized light and the small-angle X-ray scattering. While both methods are suitable for measuring the alignment degree of cylindrical nano-objects in suspensions diluted down to low concentrations, they are restricted for the application to undiluted concentrated suspensions because of non-transparency and multiple scattering of X-rays.

Determination of dimensions of exfoliating materials in aqueous suspensions.

A method for measurement of dimensions of platy particles of exfoliating, or delaminating, materials, such as clays, in aqueous suspensions in situ is proposed. Equivalent spherical diameter (esd), measured by many common methods, depends more on the major (lateral) dimension of a particle, while it is less sensitive to changes of the particle thickness. Addition of the second method, results of which are a function of the particle diameter and thickness too, would provide more accurate determination of the particle dimensions.

[Results of splenorenal venous bypass grafting in patients with hepatocirrhosis].

Presented herein are the results of surgical treatment of 79 patients with intrahepatic portal hypertension who underwent splenorenal venous bypass grafting after splenectomy. The patients' age varied from 8 to 64 years, averaging 37.3 years.