[The activity of superoxide dismutase and its isoenzymes in the immunocompetent cells of the peripheral blood in systemic lupus erythematosus and rheumatoid arthritis].

General activity of superoxide dismutase (SOD) and its isoenzymic spectrum in lymphocytes and neutrophils were studied in the peripheral blood from 63 SLP and 85 RA patients. A significant decline in SOD activity and qualitative shifts in SOD isoenzymic spectrum were found in both cell groups. The differences were specific for lymphocytes and neutrophils.

[Study of isoenzymes of lymphocyte populations during controlled immunization and in autoimmune pathology].

It has been shown that during immune system activation pronounced alterations are observed in the metabolic process course in lymphoid cells that, probably, reflect the changes in T- and B-lymphocyte functional activity, and the kinetics of intercellular relationships. The ratio of LDH1 and LDH5 fractions most differing in electrophoretic mobility has been recommended as a sign of B-system immunity activation.

[The function of lymphocyte populations based on aberrations in the lactate dehydrogenase isoenzyme spectra in systemic lupus erythematosus and rheumatoid arthritis].

The data were obtained on the presence of considerable aberrations of the isoenzymic spectrum of lactate dehydrogenase in different lymphocyte populations and subpopulations. The isoenzymic shifts reflect the changes occurring in the metabolic status of the cells and are sensitive tests detecting functional deficiency of lymphocytes.