Publications by authors named "N M Resendes"
Background: Studies have shown that frailty was increased in hospitalized COVID-19 patients. However, it is not clear whether non-severe COVID-19 increases the risk for pre-frailty and frailty development. Our study aimed to determine the risk of developing frailty and pre-frailty in robust veterans who contracted non-severe COVID-19.
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- The study investigated how high neutrophil-to-lymphocyte ratio (NLR) values correlate with inpatient mortality and clinical outcomes in older veterans hospitalized with COVID-19.
- Researchers analyzed data from 615 hospitalized veterans, finding that higher NLR values were linked to increased rates of inpatient mortality and ICU admissions.
- The findings suggest that the NLR score can help predict the risk of death in older COVID-19 patients, making it a potentially valuable clinical tool.
Objectives: Determine the association of higher FI-LAB scores, derived from common laboratory values and vital signs, with hospital and post-hospital outcomes in Veterans hospitalized with COVID-19 infection.
Design, Setting, And Participants: A retrospective, multicenter, cohort study of 7 Veterans Health Administration (VHA) medical centers in Florida and Puerto Rico. Patients aged 18 years and older hospitalized with COVID-19 and followed for up to 1 year post discharge or until death.
Many secreted or cell surface proteins are post-translationally modified by carbohydrate chains which are a primary source of heterogeneity. The Lec1 mutant, which is defective in Golgi N-acetylglucosaminyltransferase I (GnTI) activity, produces relatively homogeneous Man(5) GlcNAc(2) glycan modifications, and is widely used for various applications. To facilitate the investigation of GnTI, its Man5 glycan endproduct, and the impact of Man5 on effector function, the present study has established several novel Lec1 mutants in dhfr(-) CHO-DUKX cells through chemical mutagenesis and lectin selection.
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