Persistence of tick-borne encephalitis virus in monkeys. I. Features of experimental infection.

Sixty-seven Macaca rhesus monkeys were inoculated with 2 mutants and 3 virulent strains of tick-borne encephalitis (TBE) virus including strains isolated from patients with a chronic form of TBE. A model of the clinical course of acute, subacute, and chronic encephalitis was produced by intracerebral inoculation and that of asymptomatic infection was produced by subcutaneous inoculation [with or without administration of cyclophosphane (CP)]. Virus persistence developed after inoculation with all the strains, after non-fatal encephalitis and inapparent infection irrespective of CP administration.

[Effect of polyene antibiotics on the increase in specific resistance due to inactivated antiviral vaccines].

The capacity of polyenic antibiotics, such as water soluble forms of amphotericin B, mycoheptin, nystatin and levorin to stimulate immunogenicity and interferonogenic activity of inactivated antiviral vaccines was shown. The protective effect of the vaccine against rabies or forest-spring encephalitis in albino mice was more pronounced on its two-fold use in combination with the antibiotic than that on its use alone. The most significant results were obtained with highly diluted vaccines supplemented with amphotericin B.

[Epidemiological studies of rubella and cytomegalovirus infection in the North of the USSR].

Seroepidemiological characteristics of rubella and cytomegalovirus infection in the north of the USSR were studied. Examinations of 21,000 patients with rubella and serological survey of 1500 subjects revealed the identity of the main epidemiological indices and age changes in antibody to rubella virus in the northern and central parts of the USSR. The general percentage of seropositives to cytomegalovirus is significantly higher in the north than in other parts of the country.