Publications by authors named "N M Price"
Introduction: The 2024 Voice AI Symposium, hosted by the Bridge2AI-Voice Consortium in Tampa, FL, featured two keynote speeches that addressed the intersection of voice AI, healthcare, ethics, and law. Dr. Rupal Patel and Dr.
View Article and Find Full Text PDFThe Effect of Copper Limitation on the Bioavailability of Cu-Organic Complexes.
Environ Sci Technol
December 2024
Article Synopsis
- The study investigated how well synthetic organic copper complexes (Cu-L) and inorganic copper species (Cu') are absorbed by phytoplankton under different copper availability conditions.
- Copper bioavailability was influenced by the nutritional state of the phytoplankton and the ability of Cu' to diffuse to the cells, showing that Cu-L and Cu' both provide essential copper for growth when Cu' is above a certain threshold.
- The growth of copper-inhibited phytoplankton did not depend on Cu-L when high Cu' was present, indicating a negative correlation overall, while gene expression related to copper uptake was affected by the copper concentration.
Apolipoprotein E ( ) modifies human aging; specifically, the ε2 and ε4 alleles are among the strongest genetic predictors of longevity and Alzheimer's disease (AD) risk, respectively. However, detailed mechanisms for their influence on aging remain unclear. Herein, we analyzed inter-omic, context-dependent association patterns across genotypes, sex, and health axes in 2,229 community-dwelling individuals to test genotypes for variation in metabolites and metabolite-associations tied to a previously-validated metric of biological aging (BA) based on blood biomarkers.
View Article and Find Full Text PDFAll lineages of SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, contain mutations between amino acids 199 and 205 in the nucleocapsid (N) protein that are associated with increased infectivity. The effects of these mutations have been difficult to determine because N protein contributes to both viral replication and viral particle assembly during infection. Here, we used single-cycle infection and virus-like particle assays to show that N protein phosphorylation has opposing effects on viral assembly and genome replication.
View Article and Find Full Text PDFThe study examined changes in the plasma proteome, metabolome, and lipidome of N = 14 patients with relapsing-remitting multiple sclerosis (RRMS) initiating treatment with ocrelizumab, assayed at baseline, 6 months, and 12 months. Analyses of >4000 circulating biomarkers identified depletion of B-cell associated proteins as the early effect observed following ocrelizumab (OCR) initiation, accompanied by the reduction in plasma abundance of cytokines and cytotoxic proteins, markers of neuronaxonal damage, and biologically active lipids including ceramides and lysophospholipids, at 6 months. B-cell depletion was accompanied by decreases in B-cell receptor and cytokine signaling but a pronounced increase in circulating plasma B-cell activating factor (BAFF).
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