Publications by authors named "N M Peel"
Somatostatin receptor-4 (SST) is a therapeutic target for several conditions, including Alzheimer's disease, seizures, neuropsychiatric disorders, and pain. Our previous work on 1,2,4-triazole derivatives led to enhanced SST binding affinity, selectivity, and functional activity. Herein we report the discovery of 3-thio-1,2,4-triazole series as selective and high affinity SST agonists.
View Article and Find Full Text PDFIntroduction: Attaining movement proficiency under various constraints is well-researched; of particular interest here is how conscious processing and self-consciousness influence learning and performance. Current research relevant to these variables e.g.
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- Microtubule doublets (MTDs) consist of an incomplete microtubule attached to a complete one and are found in cilia across many species, but how they form and are maintained is not well understood.
- Research identified the protein MAP9 (and its C. elegans homolog MAPH-9) as crucial for MTD assembly, which binds specifically to MTDs, influenced by tubulin modification.
- The absence of MAPH-9 leads to structural defects in MTDs and affects cilia function, indicating that MAP9/MAPH-9 is likely important in maintaining ciliary motor regulation and MTD structure in both worms and mammals.
Background: Frailty is prevalent in older people with chronic kidney disease (CKD) and robust evidence supporting the benefit of dialysis in this setting is lacking. We aimed to measure frailty and quality of life (QOL) longitudinally in older people with advanced CKD and assess the impact of dialysis initiation on frailty, QOL and mortality.
Methods: Outpatients aged ≥65 with an eGFR ≤ 20ml/minute/1.
Background: Even though frailty has been extensively measured in the acute care setting, relatively little is known about the frailty of younger adult inpatients.
Aim: This study aimed to measure frailty in a sample of hospitalized adults aged 18 years and over and to examine how frailty in younger adult inpatients differs from middle-aged and older adult inpatients.
Design: Secondary analyses of prospectively collected cohort data.