[Morphofunctional changes in the spleen in idiopathic thrombocytopenic purpura].

Morphofunctional changes in the spleen in this disease were assessed using a number of histological, histoenzymochemical, morphometric, cytological, and immunological methods. The study included 52 operatively removed spleens. Hyperplastic changes in the white pulp varying in different age groups were demonstrated.

[Toxicologic study of the antianemia preparation dextrafer].

Experiments were conduced with a twofold purpose, viz--to determine the medium lethal dose of the preparation and to study the dextrafer distribution in tissues of rabbits after its single or repeated intravenous infusion. The medium lethal dose of the drug was found to be 250 time greater than its maximal therapeutic dose. Morphological and histochemical observations showed dextrafer to have no toxic effect on the rabbits' tissues over a period of 2 years after its single intravenous infusion.

[Several clinic-morphologic aspects and problems concerning the pathogenesis of the Marchiafava-Miche li syndrome (paroxysmal nocturnal hemoglobinuria].

The authors present a broad pathoanatomic picture and concise clinical-laboratory characteristics of Marchiafava-Micheli's disease on the basis of their studies of case record date of 31 patients, data of 13 autopsies and findings of 27 treanobiopsies. Changes in the organs observed in Marchiafava-Micheli's disease were first of all morphological manifestations of massive intravascular hemolysis and associated with latter complications The most characteristic pathoanatomic feature was changes in the bone marrow which manifested themselves in hyperplasis of nuclear forms of the red series and in drastically pronounced disorders of the microcirculation. Necrobiotic changes in the kidney accompanied by massive hemosiderosis, dystrophic changes in the liver with the development of cirrhosis, inhibition of lymphopoiesiis in the spleen and lymph nodes were detected most often.