Conjugate of pyrimidine derivative, the drug xymedon with succinic acid protects liver cells.

The aim of the study was to investigate the hepatoprotective properties of the conjugate of the xymedon drug substance with succinic acid (1a). The study presents an in vitro comparative evaluation of the cytotoxicity and cytoprotective properties of 1a and succinic acid on a cell line of normal human hepatocytes Chang Liver, and in vivo investigation of the ability of 1a to restore liver from the toxic damage caused by CCl in Wistar rats. It was shown that the cytotoxicity of 1a was 19.

[The impact of habitation environment on population alcohol consumption in Russia].

The article presents the results of analysis of complex of potential environmental factors for alcohol consumption by population of the Russian Federation. It was revealed that the level of alcoholization of residents of certain territories of the Russian Federation is positively associated with systemic severity of indices of social and criminal tension in society. The potential physical and geographical risk factors of alcohol abuse of population are severity of Northern latitude of residence and low level of average annual air temperature and longitude of day in winter season.

Rabies surveillance in the Russian Federation.

Rabies is endemic to the Russian Federation. The disease incidence ranges between 2,000 and 4,000 cases annually. Between two and six cases in humans are also reported each year.

Synthesis of new cyclic thioureas and evaluation of their metal-chelating activity, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase inhibition profiles.

In the presence of trifluoracetic acid (TFAA), an efficient method for the synthesis of tetra(hexa)hydropyrimidinethione-carboxylates has been used on the basis of three-component condensation of thiourea with its different aldehydes and β-diketones. Some novel cyclic thioureas were synthesized, and their hCA I, hCA II, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) inhibitors and metal-chelating properties were evaluated. K values of novel synthesized compounds for AChE and BChE are in the range of 51.

Evaluation of the Hepatoprotective Effect of L-Ascorbate 1-(2-Hydroxyethyl)-4,6-Dimethyl-1,2-Dihydropyrimidine-2-One Upon Exposure to Carbon Tetrachloride.

Hepatoprotective properties of a new pyrimidine derivative - L-ascorbate 1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihydropyrimidine-2-one, synthesized on the basis Xymedon, were assessed in white rats exposed to CCl4. The compound under study administered prior to exposure to CCl reduced the deviation of biochemical parameters from reference values and severity of structural and morphological changes in liver, when compared to the control. Hepatoprotective properties of the studied compound were more pronounced than those of Xymedon.