Publications by authors named "N M Morales"
RA-0003022 () was identified as a high-quality covalent chemical probe for nsP2 cysteine protease (nsP2pro). Isoxazole covalently captured the active site C478 and inactivated the enzyme with a / ratio of 6000 Ms. A negative control analog RA-0025453 () retained the covalent warhead but demonstrated >100-fold decrease in enzyme inhibition.
View Article and Find Full Text PDFObjectives: To determine the proportion of online vape shops that offer derived cannabinoid products in a large metropolitan area (San Diego, California), measure their compliance with state hemp regulations, and estimate whether these shops receive more website traffic compared to those that offered nicotine or tobacco.
Methods: We obtained vape shops (n = 109) using browser-based (i.e.
Article Synopsis
- Sclerocorneal grafts, or sclerokeratoplasty, are performed in cases involving serious damage to corneal and scleral tissues, and this study reviews their outcomes in severely diseased eyes.
- The analysis included 40 patients with a mean follow-up of about 21 months, revealing that complications occurred in 67.5% of cases, with persistent epithelial defects and ocular hypertension being the most common.
- Despite the risks, the procedure successfully preserved vision in 72.5% of eyes and maintained ocular integrity in 85%, indicating its potential as a valuable option for certain eye conditions.
Article Synopsis
- The study investigates the effectiveness of antifungal photodynamic therapy (PDT) using a combination of bisdemethoxycurcumin (BDMC) with melatonin (MLT) or acetyl-melatonin (AcO-MLT) against C. albicans biofilms.
- Findings showed significant reductions in colony forming units (CFUs) with specific combinations of BDMC and MLT, particularly notable at early post-treatment times.
- The research also highlights that MLT enhances singlet oxygen production, which correlates with antifungal efficacy, while BDMC showed minimal cytotoxic effects on human oral cells.
Lipid radicals and oxidized cholesteryl esters in low- and high-density lipoproteins in patients with β-thalassemia: Effects of iron overload and iron chelation therapy.
Free Radic Biol Med
November 2024
Article Synopsis
- Iron overload can cause problems in the heart for people with β-thalassemia because it leads to damage in the fats found in their blood.
- In a study, researchers discovered that iron overload lowers certain important fats and vitamins while increasing harmful substances in the blood, especially in β-thalassemia patients.
- They also found that using iron chelators (special medicines that remove iron) can help reduce this damage and suggested that a specific type of fat might be a good way to track the problem in these patients.