Publications by authors named "N M Mazure"
Article Synopsis
- Hematopoietic multipotent progenitors (MPPs) in the bone marrow can differentiate into various cell types, influenced by both intrinsic and extrinsic signals, with WHIM syndrome patients exhibiting an excess of myeloid cells due to CXCR4 signaling mutations.
- Research using knock-in mice with WHIM-associated mutations showed that MPP4 cells, which usually develop into lymphoid cells, instead skewed towards myeloid differentiation due to increased mTOR signaling and altered oxidative phosphorylation.
- Treatment with CXCR4 antagonist AMD3100 or mTOR inhibitor rapamycin reversed this myeloid bias, indicating that normal CXCR4 function is crucial for maintaining the lymphoid potential of MPP4 cells by regulating
The primary cilium, a non-motile organelle present in most human cells, plays a crucial role in detecting microenvironmental changes and regulating intracellular signaling. Its dysfunction is linked to various diseases, including cancer. We explored the role of ciliated cells in prostate cancer by using Gefitinib and Jasplakinolide compounds to induce ciliated cells in both normal and tumor-like prostate cell lines.
View Article and Find Full Text PDFMedulloblastoma (MB) is the most prevalent brain cancer in children. Four subgroups of MB have been identified; of these, Group 3 is the most metastatic. Its genetics and biology remain less clear than the other groups, and it has a poor prognosis and few effective treatments available.
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