[The influence of central auditory processing on the intelligibility of the speech in the patients presenting with hearing impairment].

The objective of the present study was to evaluate to what degree the function of the central auditory pathways influences the intelligibility of the speech in the patients suffering from the sensorineural loss of hearing (SNLH). The study included a total of 20 patients at the age varying from 31 to 80 years presenting with moderate to moderately severe symmetrical SNLN. All the patients were permanent hearing aid users.

[Polymorphisms of genesencoding enzymes of the xenobiotic detoxification system and the risk of infectious endocarditis].

Infectioue endocarditis (IE) is frequently associated with the use of narcotic drugs, glucocorticosteroids, and cytostatics that are metabolized in the body by enzymes of the xenobiotic detoxification system (XDS). This work was aimed at elucidating association between IE and mononucleotide polymorphisms of genes encoding XDS enzymes. 46 IE patients and 114 subjects without cardiovascular diseases (controls) underwent genotyping for polymorphic loci of cytochrome P450 1A1 gene I462V (CYP1A1), I105VandA114V gene of glutathione-S-transferase Pi1 (GSTP1) using allele-specific PCR.

[Association of leptin and total immunoglobulin E in obese patients].

We measured by the immunoenzyme assay serum levels of total IgE and leptin in 17 men and 95 women with non-alcoholic fatty liver diseases (NAFLD) and in 57 men and 25 women with alcoholic liver disease (ALD) in comparison with 454 control men and 74 women without hepatic pathology. It was shown that the total serum IgE level in patients with ALD (229.5 +/- 31.

[Peculiarities of hearing prosthetics for the patients suffering tympanophonia].

The objective of the present study was to estimate the influence of fractal tones (ZEN program) on chronic subjective tympanophonia in the patients using hearing aid apparatuses. A total of 20 subjects at the age from 30 to 69 years suffering tympanophonia in combination with grade I-IV loss of hearing were available for examination with the use of the following methods: analysis of complaints and medical histories, evaluation of ENT functioning, impedancometry, tonal threshold, suprathreshold and speech audiometry, psychoacoustic noise measurement, analysis of THI and TRQ questionnaires. The results of the questionnaire studies show that the use of the ZEN program and hearing aid apparatuses (Mind 440, WIDEX) decreased the intensity of tympanophonia in 90% of the patients.

[Chronic inflammatory and dystrophic diseases of the eye anterior segment and their association with genetic polymorphisms in workers of metallurgic industry].

The ophthalmologic investigation of workers of the two metallurgical enterprises has shown that 1045 persons (55%) from 1911 observed workers suffer chronic diseases of a forward piece of eyes. Chronic inflammatory diseases (blepharitis, conjunctivitis and blepharoconjunctivitis) are found at 28,9% of them, and dystrophic diseases (pinguecula/pterygium)--at 25,8%. Among metallurgists (1801 persons) ophthalmopathy was found in 2, 2 times more often than at persons in control group (110 observed engineers and managers).