[Immunopathology in the children and adolescents living in regions with a varying anthropogenic load].

The prevalence and pattern of immunopathology were analyzed in the children and adolescents living in the Orenburg Region's areas having a varying anthropogenic load. The children and adolescents were found to have high morbidity rates for allergic, infectious-and-inflammatory diseases upon anthropogenic exposure. In the examinees, the immunological parameters corresponded to the stereotypic changes that were characteristic of infectious-and-inflammatory and allergic syndromes.

[Influence of plasmid pR50 controlling bacterial protease activity on Salmonella experimental infection].

The comparative analysis of the infectious process and immunological parameters in (CBA x C57BL/6)F1 mice infected with S. typhimurium isogenic strains differing by the presence of plasmid pR50 determining protease activity, was carried out. A growth in the expression level of antilactoferrin, anticomplementary and anti-immunoglobulin activity in bacteria isolated from the spleen in the course of the infectious process was detected.

[Preclinical study of maxar safety].

The results of preclinical safety evaluation of the new hepatoprotector maxar showed that this drug can be classified as a low-toxicity substance with respect to acute toxicity. No significant functional and structural changes in the systems and organs of experimental animals were observed after a 6-month administration in rats (in a dose of 300, 600, and 1200 mg/kg) and in dogs (500 mg/kg). Maxar exhibited no mutagen and allergen properties, produced no immunotoxicant action, and did not adversely affect the reproduction function.

[A preclinical trial of iodoantipyrine safety].

Detailed preclinical study of the safety of the new antiviral agent iodantipyrine was conducted. In LD50 parameters it was found to be related to moderately toxic drugs. Long-term administration in doses of 50, 100, and 250 mg/kg did not cause any essential functional and structural disorders in the organs and systems of rats and dogs.

[Characteristics of the radio-ecologic situation in the area of Totsk nuclear explosion and the immune status of schoolchildren residing in the vicinity].

Environmental pollution caused by radioactive and non-radioactive chemicals, and the immunity of schoolchildren who reside in the area exposed to the Totsk nuclear explosion (1954) are comparatively analyzed. The results indicate that the area under study has higher levels of 137Cs than that of a control area. There were immunological changes in children, which are obviously associated with the nuclear explosion.