Background: In 2004, wheat flour fortification (WFF) with iron was implemented in Kazakhstan as a public health strategy to increase the iron intake of all women of childbearing age and of children. In 2003, before starting the flour fortification program, a communication campaign on health education took place in a region with a high prevalence of iron deficiency anemia (IDA). The present study aimed to evaluate the prevalence of anemia, iron deficiency and IDA before and after the campaign.
View Article and Find Full Text PDFAn assessment of nutritional status children under 3-years old was given, which conducted within Kazakstan Dimography Health Survey, 1995. 717 children under 3 years old were examined, including Kazak--421, Russian--161 and other ethnicities--135. An assessment of nutritional status was conducted by the anthropometric indices: Height/Age, Weight/Height, Weight/Age.
View Article and Find Full Text PDFThe aim of the experiment was to study the effect of three specialized food rations on activity of superoxide dismutase (SOD) in tissues of rats with transplanted Walker's carcinosarcoma 256 exposed to carminomycin. It was shown that the three specialized rations were able to significantly modify the SOD activity in the tissues of the rats with Walker's carcinosarcoma 256 at the background of treatment with carminomycin. Thus, the ration enriched with copper and zinc salts and folic acid activated SOD in the animals of all the groups.
View Article and Find Full Text PDFThe state of the thiol-dependent systems i.e. concentration of the SH-groups, activity of glutathione reductase and glutathione-S-transferase, carminomycin antitumor and toxic effects was studied under conditions of tumor growth and carminomycin therapy with the use of prophylactic rations (PR) aimed at stimulating the cell thiol-dependent and antioxidant systems for decreasing the drug toxic action.
View Article and Find Full Text PDFThe influence of carminomycin (CM) on enzymic systems of metabolism of oxygen active forms, free radical lipid peroxidation and microviscosity of membrane lipids as well as toxic and antitumour action of CM were studied in normal and tumour-bearing rats. Detected responses of the system of superoxide anion- and H2O2 metabolism reflected the role of active oxygen forms in CM toxicity. The investigation results of the lipid peroxidation fluorescent products level and microsomal lipid phase microviscosity did not suppose stimulation of lipid peroxidation as key mechanism for CM toxic effects.
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