The genus Gnetum: Traditional use, phytochemistry, nutritional value, biosynthesis, synthesis, pharmacology, toxicology, synthetic advance, and pharmacokinetics.

Background: Gnetum is the sole genus within the family Gnetaceae. Numerous species are edible, their seeds can be roasted, and the leaves can be consumed as vegetables. Gnetum plants have been highly esteemed in traditional folk medicine worldwide for many years.

Polyethylene glycol hexadecyl ether modified heparin for paclitaxel nano-delivery system.

A paclitaxel (PTX) nano-delivery system using modified heparin and polyethylene glycol hexadecyl ether (Brij 58) was developed in this study. Brij 58 was conjugated to the heparin backbone via the cystamine bridge and donated as Hep-Brij 58 to facilitate the self-assembly into stable nanoparticles in aqueous. The self-assembled formation of Hep-Brij nanoparticles was demonstrated through DLS and TEM, whereas the iodine method identified the critical concentration for the self-assembled process.

Effects of 100 IU versus 150 IU hCG supplementation on oocyte and embryo quality in patients aged ≥ 35 years: a propensity score-matched analysis.

The optimal dose of human chorionic gonadotropin (hCG) supplementation during controlled ovarian stimulation (COS) remains controversial, particularly in women of advanced reproductive age. To compare the efficacy and safety of 150 IU versus 100 IU daily hCG supplementation from stimulation day 6 in women aged ≥ 35 years undergoing fertilization/intracytoplasmic sperm injection (IVF/ICSI). In this retrospective cohort study, we analyzed data from 438 patients aged ≥ 35 years undergoing IVF at a single center.

Fewer good-quality cleavage embryos in dydrogesterone-primed ovarian stimulation compared to GnRH antagonist protocol in POSEIDON group 4 patients.

Objective: To compare the in vitro fertilization (IVF) outcomes of the progestin-primed ovarian stimulation (PPOS) protocol using dydrogesterone and the GnRH antagonist (GnRH-ant) protocol in POSEIDON group 4 patients.

Methods: This retrospective cohort study analyzed 447 POSEIDON group 4 patients who underwent IVF at a single center. Patients were categorized into GnRH-ant (n = 281) and PPOS (n = 166) groups.

Anakinra for dengue patients with hyperinflammation: protocol for a randomized double-blind placebo-controlled trial.

Background: Novel host-directed therapies are urgently needed for patients with dengue, particularly those at high risk of developing severe disease. Broad immunosuppression using corticosteroids in unselected patients with dengue has so far been unsuccessful. Patients with hyperinflammation (raised CRP and/or ferritin levels) are at highest risk of poor outcomes in dengue.