NK Cell Exosomes Alleviate PD-L1 Expression and Facilitate Tumor Immunity by Repressing PI3K-AKT-mTOR Signaling.

Background: Liver cancer (LC) is a deadly malignancy with limited therapeutic options in recent years. Natural killer cell-derived exosomes (NK-exo), as an important bridge of information transmission between cells, also have a certain killing effect on tumor cells. On this basis, this study investigated the specific regulatory mechanism of NK-exo on LC cells.

Novel and efficient yeast-based strategies for subunit vaccine delivery against COVID-19.

Yeast shows promise as a delivery system for drugs and vaccines due to its specific targeting and immunogenic properties. The objective of this research is to create novel and effective yeast-based methods for delivering subunit vaccines. Through the modification of yeast expression plasmids and optimization of expression techniques, a new dual-expression system has been developed.

Grazing increases the complexity of networks and ecological stochastic processes of mycorrhizal fungi.

Arbuscular mycorrhizal fungi (AMF) form extensive symbiotic relationships with plants, which are critical for plant-driven biogeochemical cycles and ecosystem functions. Grazing and mowing, which are common grassland utilization patterns globally, significantly alter plant community characteristics as well as soil nutrients and structure, thereby potentially influencing AMF communities. However, the effects of these grassland managements on AMF community structure and ecological processes remain unclear.

Role of Individual and Network Factors in HIV Care Continuum Outcomes among PLWH: An Egocentric Network Study in Yunnan, China.

Due to limited data on the determinants of HIV care continuum outcomes among people living with HIV (PLWH) in resource-limited settings, this study aimed to identify individual and social support network factors influencing these outcomes, thereby informing the development of intervention strategies to achieve the UNAIDS 95-95-95 targets. PLWH in Yunnan, China, were recruited using convenience sampling at three stages of the HIV care continuum: linkage to care, antiretroviral therapy (ART) initiation, and viral suppression. An egocentric network design combined with multilevel logit modeling was employed to investigate factors associated with ART initiation and viral suppression.

Validation and improvement of the molecular international prognostic scoring system in Chinese patients with myelodysplastic syndromes.

Various prognostic models have been proposed to improve the accuracy of prognostic assessment for Myelodysplastic syndromes (MDS). Recently, the Molecular International Prognostic Scoring System (IPSS-M) has been developed. Here, we validated the accuracy of IPSS-M in Chinese MDS patients, and proposed a prognostic model more suitable for Chinese patients.