Publications by authors named "N M Hettiarachchi"
Article Synopsis
- The study assessed the effectiveness of bivalent and monovalent mRNA COVID-19 boosters among UK healthcare workers from October 2023 to March 2024 during the circulation of the XBB.1.5 and JN.1 variants.
- Among 2867 participants, about half received a booster, and 19% experienced confirmed infections; the monovalent booster showed better effectiveness compared to the bivalent one, especially in the first two months post-vaccination.
- Results indicated that recent infections boosted immunity, and the findings suggest that tailored vaccines for circulating variants could be beneficial for seasonal immunization among healthcare workers.
The voltage-gated K channel plays a key role in atrial excitability, conducting the ultra-rapid rectifier K current (I) and contributing to the repolarization of the atrial action potential. In this study, we examine its regulation by hydrogen sulfide (HS) in HL-1 cardiomyocytes and in HEK293 cells expressing human Kv1.5.
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- The SIREN study began in June 2020, focusing on PCR testing and sequencing in UK healthcare workers to monitor SARS-CoV-2 infections and reinfections.
- It identified a rise in infections and reinfections, as well as the emergence of Omicron subvariant waves, aligning with national data.
- SIREN's approach serves as an effective method for ongoing variant surveillance.
Objectives: To investigate serological differences between SARS-CoV-2 reinfection cases and contemporary controls, to identify antibody correlates of protection against reinfection.
Methods: We performed a case-control study, comparing reinfection cases with singly infected individuals pre-vaccination, matched by gender, age, region and timing of first infection. Serum samples were tested for anti-SARS-CoV-2 spike (anti-S), anti-SARS-CoV-2 nucleocapsid (anti-N), live virus microneutralisation (LV-N) and pseudovirus microneutralisation (PV-N).