[The correlation of expression of MUC1, ICAM1, IL32, FcyR3A and FoxP3 in tumor niduses of patients with breast cancer].

The hypo-glycated mucin I (MUC I) frequently is redundantly expressed in cells of breast carcinoma that is considered as an unfavorable prognostic marker for patients with breast cancer. The purpose of study is to evaluate in tumor areas of patients with breast cancer the interrelationships between expression of MUC I and genes participating in implementation of immune reactions. The technique of polymerase chain reaction with reverse transcription in real-time was applied to investigate expression of genes of MUC I, Fas, ICAMI, FcyR3A, FcyR3B, FoxP3, IL2Ra, IL32 and TNF in tumor areas of 40 patients with breast cancer.

Do commonly used frailty models predict mortality, loss of autonomy and mental decline in older adults in northwestern Russia? A prospective cohort study.

Background: Frailty prevalence differs across countries depending on the models used to assess it that are based on various conceptual and operational definitions. This study aims to assess the clinical validity of three frailty models among community-dwelling older adults in north-western Russia where there is a higher incidence of cardiovascular disease and lower life expectancy than in European countries.

Methods: The Crystal study is a population-based prospective cohort study in Kolpino, St.

[Role of MUC1 Expression in Tumor Progression].

Mucin 1 (MUC1) is a multistructural and multifunctional protein that is involved in regulating diverse cellular activities. This strongly glycosylated transmembrane protein forms a mucous gel on the surface of epithelial cells that protects the cells from injury. MUC1 acts as a signaling molecule and transcription factor modulating metabolism and resistance to bacterial-induced inflammation.

The relationship between physical performance and cardiac function in an elderly Russian cohort.

This study aims to determine the cardiac dysfunction prevalence, to investigate the relationship between the Short Physical Performance Battery (SPPB) test and structural and functional echocardiographic parameters and to determine whether SPPB scores and cardiac dysfunction are independent mortality predictors in an elderly Russian population. A random sample of 284 community-dwelling adults aged 65 and older were selected from a population-based register and divided into two age groups (65-74 and ≥75). The SPPB test, echocardiography and all-cause mortality were measured.

[The health status of the elderly patients in a St. Petersburg district: results of Crystal project].

Using the "Crystal" study as an example of an epidemiological study that investigates global health of the elderly, the potential of a comprehensive geriatric assessment in primary care is illustrated. The results of the first cross-sectional data collection are presented in this paper with emphasis on the global health picture of the elderly; the average age was 75.08 +/- 5.