Publications by authors named "N M Ghiasvand"
Article Synopsis
- A study on early-onset progressive cerebellar ataxia in Iran was conducted at the Children's Medical Center from 2019 to 2022, focusing on genetic factors and patient data.
- Researchers examined 162 patients, identifying pathogenic genetic variants in 42 genes across 97 families, achieving a genetic diagnostic rate of nearly 60%.
- The findings highlight Iran's diverse genetic causes of hereditary ataxia, emphasizing the need for preventive strategies and a national guideline to enhance diagnosis and patient care.
The retinal ganglion cell (RGC) competence factor ATOH7 is dynamically expressed during retinal histogenesis. transcription is controlled by a promoter-adjacent primary enhancer and a remote shadow enhancer (SE). Deletion of the human SE causes nonsyndromic congenital retinal nonattachment (NCRNA) disease, characterized by optic nerve aplasia and total blindness.
View Article and Find Full Text PDFBy using the streptozotocin- (STZ-) induced cytotoxicity in -TC3 cells as an assay model, a bioassay-guided fractionation study was employed to isolate and characterize the potential antidiabetic principles of roots of A combination of open column chromatography on reverse-phase silica gel using a water-ethanol gradient (10 : 90 to 100 : 0) followed by HPLC-based fractionation led to an active compound that appears to be composed of carbohydrate/sugar. When cell viability under STZ was reduced to 49.8 ± 4% (mean ± SD), treatment with the active compound at the concentration of 0.
View Article and Find Full Text PDFObjective: Parkinson's disease, a slowly progressive neurological disease, is associated with degeneration of the basal ganglia of the brain and a deficiency of the neurotransmitter dopamine. The main aspects of researches are the protection of normal neurons against degeneration. Fatty acids (FAs), the key structural elements of dietary lipids, are carboxylic straight chains and notable parameters in nutritional and industrial usefulness of a plant.
View Article and Find Full Text PDFObjectives: The present study aims to evaluate the protective effect of the compounds isolated from () against oxidative stress and apoptosis induced by cisplatin (CIS) in PC12 cells.
Materials And Methods: Six compounds were isolated as quercetrin-3---D-glucopyranoside (QUE), osthol (OST), verbenone-5---D-glycopyranoside (VER), Isoimperatorin (ISO), kaempferol-3---D-glucopyranoside (KAM), and echinophorin B (ECH). For this study, we used MTT reduction assay for detection of protective effects of isolated compounds on CIS-induced cytotoxicity in PC12 cells.