Effect of head-down hanging on the course of degenerative process in the hind paw muscles of 12-month-old MDX mice.

Effect of functional unloading on the course of degenerative process in muscles was studied in dystrophin-deficient mdx mice. Head down-hanging of animals led to a significant decrease in the cross-section area of muscle fibers, increase in the percentage of fibers with centrally located nuclei and of Evans blue-stained fibers. Gravitation unloading of 12-month-old animals with pronounced manifestations of muscular dystrophy did not inhibit this pathological process.

[Creatine as a metabolic controller of skeletal muscles structure and function in strength exercises in humans. The cellular mechanisms].

The effects of creatine oral supplementation combined with a 10-week resistive training of morphometric, contractile and molecular characteristics of human vast lateral muscle fibers were studied. 2 groups consisting of 9 young healthy men each were involved in resistive training of knee extensors for 10 weeks. Volunteers of the first group received per os 20 g of creatine for the 1st week of training and 5 g for the rest of the experimental training period.

[Serum creatine kinase levels and the number of sarcolemmal dystrophin disruptions in human skeletal muscle fibers under conditions of weightlessness simulation].

9 male volunteers took part in the experiment. They were divided in two groups. 5 volunteers (control group) have been in "dry" immersion for 7 days.

Serum creatine kinase levels and the number of sarcolemmal dystrophin disruptions in human skeletal muscle fibers under conditions of 7-day "dry" immersion.

9 male volunteers took part in the experiment. They were divided in two groups. 5 volunteers (control group) have been in "dry" immersion for 7 days.