Synthetic approaches for novel fused pyrimidine derivatives: Design, structural characterization, antiviral, antitumor, and molecular docking evaluation.

The goal of this work was to synthesize new compounds for anticancer evaluation as a trial to obtain new antitumor agents with higher activity and fewer side effects. Therefore, the precursor 2,2'-(1,4-phenylenebis (thiazole-4,2-diyl))bis (3-(dimethylamino)acrylonitrile) was used to synthesize various azolopyrimidine derivatives connected to the thiazole moiety. Compounds -, including pyrazolopyrimidine, triazolopyrimidine, and others, were produced by reacting enaminonitrile with different -nucleophiles.

Optical, Opto-Mechanical, and Antimicrobial Characterization of TiO and ZnO-Enhanced Polypropylene Fibers Using Interferometric Techniques and Fourier Transform Analysis.

This study investigates the optical, mechanical, and antimicrobial properties of polypropylene (PP) fibers enhanced with titanium dioxide (TiO) and zinc oxide (ZnO) nanoparticles. Using a Mach-Zehnder interferometric system, we examined the refractive indices, birefringence, and opto-mechanical behavior of blank PP, PP/TiO, and PP/ZnO nanocomposite fibers under various conditions, including different polarization orientations and during cold drawing processes. The 2D Fourier transform algorithm is employed to analyze interferometric data, enabling precise measurements of refractive index profiles and birefringence.

Novel amino-functionalized MOF-based sensor for zinc ion detection in water and blood serum samples.

Aquatic systems with low zinc levels can experience a significant decrease in carbon dioxide uptake and limited growth of phytoplankton species. In this study, we describe the use of a new fluorescent sensor based on NH-MIL-53(Al), and modified with glutaraldehyde and sulfadoxine, for selectively detecting zinc ions in water and blood serum samples. Characterization of the synthesized material was performed using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), Brunauer-Emmett-Teller (BET) surface area analysis, X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM), confirming successful functionalization and preservation of the MOF structure.

Molecular modelling and antimicrobial activity of newly synthesized benzothiazolo[3,2-]pyrimidine clubbed thiazole derivatives.

A series of benzothiazolopyrimidine-thiazole conjugates , , and were produced through the reactions of 8-acetylbenzothiazolopyrimidine-thiosemicarbazone compound with chloroacetone, (un)substituted phenacyl chlorides, and ethyl chloroacetate, respectively. Based on DFT study, the synthesized conjugates had a twisted shape, except for the parent benzothiazolopyrimidine and its thiosemicarbazone compound , which were flat. The study of FMO's also showed that the substituted thiazole derivatives and have equivalent configurations of HOMO and LUMO, as well as exhibiting the least FMO's gap (ΔE).

Synthesis of designed new 1,3,4-oxadiazole functionalized pyrano [2,3-f] chromene derivatives and their antimicrobial activities.

Diethyl 2-(((4-methyl-2-oxo-2H-chromen-7-yl)oxy)methylene)malonate was synthesized from coumarin 1 and diethyl ethoxymethylene malonate in ethanol, followed by cyclization in diphenyl ether to give chromene-9-carboxylate . Sugar hydrazones were formed by reacting hydrazide with D-galactose, D-mannose, and D-xylose, then acetylated to per--acetyl derivatives . Heating with acetic anhydride at 100 °C gave oxadiazolines .