Publications by authors named "N M Bazhan"
Article Synopsis
- The study explored how the timing of starting an obesogenic diet (Cafeteria Diet) affects obesity traits in male and female mice, focusing on pre-puberty and post-puberty initiation.
- Male mice that started the diet before puberty displayed better metabolic health with lower body weight and improved fat metabolism compared to those starting after puberty.
- Conversely, female mice starting the diet before puberty showed poorer metabolic profiles, including higher triglycerides and lower insulin sensitivity, showcasing gender differences in diet impact on obesity development.
Studying sex differences in responses to fibroblast growth factor 21 administration in obese mice consuming a sweet-fat diet.
Vavilovskii Zhurnal Genet Selektsii
July 2023
In animals, obesity caused by consumption of a sweet-fat diet (SFD) is the most adequate mouse model of human diet-induced obesity. Fibroblast growth factor 21 (FGF21) reduces body weight, beneficially affects taste preferences, and corrects glucose metabolism in obese mice. Sex is known to influence FGF21 effects in different models of diet-induced and hereditary obesity.
View Article and Find Full Text PDFEstradiol-dependent and independent effects of FGF21 in obese female mice.
Vavilovskii Zhurnal Genet Selektsii
March 2022
The f ibroblast growth factor 21 (FGF21) synthesized in the liver, acting as a hormone, increases insulin sensitivity and energy expenditure. FGF21 administration has potent benef icial effects on obesity and diabetes in humans, cynomolgus monkey, and rodents. The therapeutic effects of FGF21 have been studied mainly in males.
View Article and Find Full Text PDFArticle Synopsis
- FGF21 shows potential as a treatment for obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD), but its effects vary between male and female mice with mutations impacting melanocortin receptors.
- A study found that female mice had higher obesity rates and different metabolic responses compared to males after FGF21 treatment, indicating sex plays a role in how FGF21 affects metabolism.
- While FGF21 increased food intake and activity in both sexes, it only improved metabolic issues like hyperinsulinemia and liver fat in male mice, suggesting the treatment's benefits are more significant for males.
We introduce a scheme of a photonic coupler built of two parallel topological-insulator slab waveguides with the intrinsic Kerr nonlinearity, separated by a lattice spacing. Josephson oscillations (JOs) of a single edge quasi-soliton (QS) created in one slab, and of a pair of QSs created in two slabs, are considered. The single QS jumping between the slabs is subject to quick radiative decay.
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