Publications by authors named "N M Bayoumy"
Article Synopsis
- 5-fluorouracil (5-FU) is an effective chemotherapy drug but can cause liver damage, necessitating research into protective agents like thymol, a compound found in thyme.
- Administration of thymol alongside 5-FU in rats showed it could reduce liver injury by boosting antioxidant levels and improving apoptotic markers.
- The study demonstrated, for the first time, thymol's ability to protect the liver by potentially modulating key signaling pathways involved in oxidative stress and apoptosis.
Role of IRE1α/XBP1/CHOP/NLRP3 Signalling Pathway in Neonicotinoid Imidacloprid-Induced Pancreatic Dysfunction in Rats and Antagonism of Lycopene: In Vivo and Molecular Docking Simulation Approaches.
Toxics
June 2024
Imidacloprid (IMI) is a commonly used new-generation pesticide that has numerous harmful effects on non-targeted organisms, including animals. This study analysed both the adverse effects on the pancreas following oral consumption of imidacloprid neonicotinoids (45 mg/kg daily for 30 days) and the potential protective effects of lycopene (LYC) administration (10 mg/kg/day for 30 days) with IMI exposure in male Sprague-Dawley rats. The apoptotic, pyroptotic, inflammatory, oxidative stress, and endoplasmic reticulum stress biomarkers were evaluated, along with the histopathological alterations.
View Article and Find Full Text PDFCoronary artery disease is a leading cause of morbidity and mortality worldwide. It occurs due to a combination of genetics, lifestyle, and environmental factors. Premature coronary artery disease (PCAD) is a neglected clinical entity despite the rising number of cases worldwide.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to evaluate whether acetylcholinesterase inhibitors contribute to a higher risk of fractures in dementia patients by conducting a meta-analysis of existing research.
- - Researchers analyzed seven observational studies with over 564,000 participants and found no significant difference in fracture rates between those taking the inhibitors and those who were not.
- - The results suggested that long-term use of acetylcholinesterase inhibitors could actually reduce fracture risk, indicating they may be a safe treatment option for cognitive improvement in elderly patients with dementia.
Objectives: This study was conducted to study the expression of both microRNA-29a and microRNA-122, and serum levels of sestrin-2, interleukin-6 (IL-6), and other inflammatory markers among obese children with/and without diabetes mellitus.
Methods: One hundred obese children with diabetes in addition to 100 age- and sex-matched obese children without diabetes, and 100 age- and sex-matched apparently healthy children were included in the study. Expressions of both microRNA-29a and microRNA-122, and serum levels of sestrin-2, IL-6, tumor necrosis factor-α (TNF-α), and high sensitive-CRP (hsCRP) were measured for all included study populations.