Publications by authors named "N M Batelaan"
Background: This scoping review focuses on the occurrence of tachyphylaxis, defined as reduced responsiveness upon reinitiating a previously effective medication. This phenomenon is previously documented in antidepressants and mood stabilizers.
Aim: To explore the frequency, treatment strategies, and predictability of tachyphylaxis across all psychotropic medications.
Increased Amygdala Activation during Symptom Provocation Predicts Response to Combined Repetitive Transcranial Magnetic Stimulation and Exposure Therapy in Obsessive-Compulsive Disorder in a Randomized Controlled Trial.
Biol Psychiatry Cogn Neurosci Neuroimaging
November 2024
Article Synopsis
- This study explores how brain activation during symptom provocation tasks can predict the effectiveness of a combined treatment of rTMS and ERP for patients with treatment-resistant OCD.
- Sixty-one adults with OCD participated in fMRI scans to measure brain activity in response to OCD-related stimuli before undergoing an 8-week treatment regimen, with multiple rTMS applied to different brain areas.
- Results indicated that higher activation in the right amygdala prior to treatment was associated with a better response to therapy, while activation in the dorsal anterior cingulate cortex had a negative association with treatment outcomes.
Background: Non-invasive brain stimulation, such as repetitive transcranial magnetic stimulation (rTMS), is increasingly used in the treatment of neurological diseases and psychiatric disorders. Where rTMS is already an accepted treatment option for depression, in the Netherlands/Belgium, no consensus exist on the application of rTMS for (obsessive-compulsive disorder (OCD). People with OCD who do not respond enough to exposure therapy and serotonergic antidepressants are in great need for treatment alternatives.
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- Mood and anxiety disorders can affect people in different ways, and researchers studied how these conditions change over time.
- They looked at data from a survey of thousands of adults over several years to find out about different types of mood and anxiety disorders.
- They discovered four main groups of people, with most being healthy, while those with panic and phobia disorders tended to stay unwell longer and may need more help.
Background: Repetitive transcranial magnetic stimulation (rTMS) has the potential to increase the clinical effect of exposure with response prevention psychotherapy for obsessive-compulsive disorder (OCD). We investigated the use of task-based functional magnetic resonance imaging for predicting clinical outcomes to different rTMS protocols combined with exposure with response prevention in OCD.
Methods: Sixty-one adults with OCD underwent rTMS and exposure with response prevention and were randomized to different high-frequency rTMS conditions: left dorsolateral prefrontal cortex (n = 19), left presupplementary motor area (n = 23), and control stimulation at the vertex at low intensity (n = 19).