[Cytotoxic activity of the lymphocytes of mice immunized with the influenza virus and its membrane protein].

The cytotoxic activity of spleen lymphocytes of mice C3H and C3HA lines immunized with whole virions and membrane protein of influenza A/PR8/34 virus strain was studied. The cytotoxic activity of lymphocytes of mice immunized with whole virions was found to be higher for cells of primary mouse kidney cultures inoculated with the homologous virus than for cells of a continuous L929 line. The cytotoxic lymphocytes formed in response to the inoculation with membrane protein have a higher lysing activity for target cells of the continuous L929 line.

[Immune response of mice to experimental influenza].

The immune response of BALB/c mice to a pathogenic and nonpathogenic strains of influenza type A virus was studied. In this system of experimental influenza infection the pathogenic influenza A/PR8/34 (HON1) virus was found to induce sensitization of T-lymphocytes and production of clones cytotoxic for syngeneic target cells. Nonpathogenic influenza A/Krasnodar/101/59 (H2N2) virus had a less marked capacity to induce sensitization of lymphocytes and production of clones cytotoxic for syngeneic target cells.