Publications by authors named "N M Al-Namnam"
Objectives: Ultrasonic (US) cutting of cartilage in orthopaedic surgery has received little attention despite its potential to reduce chondrocyte death which could enhance cartilage repair. We aimed to investigate whether an ultrasonically-vibrating scalpel to cut human articular cartilage could reduce chondrocyte death, and to determine if hyper-osmolarity could provide chondroprotection during the procedure.
Methods: A scalpel (no.
Article Synopsis
- Alloplasts are synthetic, biocompatible materials used to repair bone defects, with their acceptance by host tissues influenced by factors like pore size and inter-connectivity.
- Recent advances in synthetic bone substitutes include calcium phosphate cements, bioactive glasses, and polymer-based options like polycaprolactone, with calcium compounds showing the most promise.
- Products like EthOss Regeneration have gained recognition for their effectiveness, and ongoing clinical trials are exploring further applications, indicating a shift towards alternatives to traditional bone grafts.
Apert syndrome is a genetic disorder characterised by craniosynostosis and structural discrepancy of the craniofacial region as well as the hands and feet. This condition is closely linked with fibroblast growth factor receptor-2 (FGFR2) gene mutations. Gene therapies are progressively being tested in advanced clinical trials, leading to a rise of its potential clinical indications.
View Article and Find Full Text PDFCrouzon syndrome exhibits considerable phenotypic heterogeneity, in the aetiology of which genetics play an important role. mediates extracellular signals into cells and the mutations in the gene cause this syndrome occurrence. Activated signaling disrupts the balance of differentiation, cell proliferation, and apoptosis via its downstream signal pathways.
View Article and Find Full Text PDFOur aim was to summarise current published evidence about the prognosis of various techniques of craniofacial distraction osteogenesis, particularly its indications, protocols, and complications. Published papers were acquired from online sources using the keywords "distraction osteogenesis", "Le Fort III", "monobloc", and "syndromic craniosynostosis" in combination with other keywords, such as "craniofacial deformity" and "midface". The search was confined to publications in English, and we followed the guidelines of the PRISMA statement.
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