Publications by authors named "N Luan"
Purpose: Increased clinical manifestations combined with increased lung imaging findings during antifungal therapy are often misjudged as failure of antifungal therapy, and should be vigilant against immune reconstitution inflammatory syndrome.
Case: We describes a case of invasive pulmonary Aspergillus infection after Influenza A Virus (IAV). After active antifungal therapy, the patient's clinical symptoms continued to worsen, imaging lesions continued to progress, laboratory indicators improved, and immune reconstitution inflammatory syndrome was considered.
Article Synopsis
- The study investigates the presence of nitrosamine-related impurities and AZBT in sartan medications, classifying them as human mutagens and carcinogens based on long-term treatment effects.
- A new, efficient method was developed for simultaneous quantification of these impurities using reversed-phase liquid chromatography combined with tandem mass spectrometry.
- The method showed high extraction efficiency, wide linear range, and strong recovery rates, and was applied to analyze 16 losartan samples, finding AZBT in some but no nitrosamine impurities in any.
Article Synopsis
- Dental pulp stem cells (DPSCs) have potential for nerve repair, but the specifics of how they differentiate into neural cells need more exploration, particularly regarding the Wnt signaling pathways.
- This study focused on the Wnt/Ca pathway's role in differentiating human DPSCs into neural cells and how it affects the Wnt/β-catenin pathway, involving experiments with neurogenic induction and various molecular assays.
- Results indicated that Wnt/Ca pathway activity decreased during neurogenic induction, leading to increased signaling through the Wnt/β-catenin pathway and promoting higher levels of neural differentiation in the DPSCs. *
Diarrheal disease continues to be a major cause of global morbidity and mortality among children under 5 years of age. To address the current issues associated with oral attenuated rotavirus vaccines, the study of parenteral rotavirus vaccines has promising prospects. In our previous study, we reported that rotavirus nonstructural protein 4 (NSP4) did not increase the IgG antibody titer of co-immune antigen but did have a protective effect against diarrhea via the intramuscular injection method.
View Article and Find Full Text PDFThrombotic diseases, emerging as a global public health hazard with high mortality and disability rates, pose a significant threat to human health and longevity. Although current antithrombotic therapies are effective in treating these conditions, they often carry a substantial risk of bleeding, highlighting the urgent need for safer therapeutic alternatives. Recent evidence has increasingly pointed to a connection between elastase activity and thrombosis.
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