Publications by authors named "N Lohr"
Mushroom-forming fungi exhibit a distinctive ecology, which is unsurprisingly also reflected in unique and divergent biosynthetic pathways. We review this phenomenon through the lens of the polyketide metabolism, where mushrooms often deviate from established principles and challenge conventional paradigms. This is evident not only by non-canonical enzyme architectures and functions but also by their propensity for multi-product synthases rather than single-product pathways.
View Article and Find Full Text PDFRegioselective Oxidative Phenol Coupling by a Mushroom Unspecific Peroxygenase.
Angew Chem Int Ed Engl
October 2024
Bioactive dimeric (pre-)anthraquinones are ubiquitous in nature and are found in bacteria, fungi, insects, and plants. Their biosynthesis via oxidative phenol coupling (OPC) is catalyzed by cytochrome P450 enzymes, peroxidases, or laccases. While the biocatalysis of OPC in molds (Ascomycota) is well-known, the respective enzymes in mushroom-forming fungi (Basidiomycota) are unknown.
View Article and Find Full Text PDFRed light (670 nm) energy controls vasodilation via the formation of a transferable endothelium-derived nitric oxide (NO)-precursor-containing substance, its intracellular traffic, and exocytosis. Here we investigated the underlying mechanistic effect of oxidative stress on light-mediated vasodilation by using pressure myography on dissected murine arteries and immunofluorescence on endothelial cells. Treatment with antioxidants Trolox and catalase decreased vessel dilation.
View Article and Find Full Text PDFArticle Synopsis
- TRPS1 is a nuclear protein found in breast epithelial cells and has potential as a breast cancer marker, based on a study analyzing 19,201 samples from various tumor types.
- In breast carcinomas, low TRPS1 expression correlates with aggressive features like high grade and nodal metastasis, but does not predict patient survival.
- The combination of TRPS1 and GATA3 immunostaining enhances cancer identification, particularly for breast and salivary gland tumors, while TRPS1 negativity helps differentiate urothelial carcinoma from breast cancer.
Background: The aim of the study was to determine the impact that PHTLS course participation had on self-confidence of emergency personnel, regarding the pre-hospital treatment of patients who had suffered severe trauma. Furthermore, the goal was to determine the impact of specific medical profession, work experience and prior course participation had on the benefits of PHTLS training.
Methods: A structured questionnaire study was performed.