Publications by authors named "N Lintern"
Background: Surgical resection for pancreatic ductal adenocarcinoma (PDAC) entails the excision of the primary tumour and regional lymphadenectomy. This traditional strategy is challenged by the high rate of early recurrence, suggesting inadequate disease staging. Novel methods of intra-operative staging are needed to allow surgical resection to be tailored to the disease's biology.
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- - This study investigated using bionanovesicles for delivering a photosensitizer drug into cholangiocarcinoma cells to enhance photodynamic therapy (PDT) outcomes.
- - Two types of bionanovesicles were created from cholangiocarcinoma cells, characterized for size, stability, and efficiency, and shown to effectively deliver the photosensitizer with no toxicity associated with dark conditions.
- - The results indicated that these vesicles could successfully disperse the photosensitizer inside tumor cells and achieved higher PDT efficiency compared to traditional methods using liposomal forms.
Article Synopsis
- - Theranostic nanoparticles, designed for both imaging and therapy, target colorectal cancer by focusing on the overexpressed carcinoembryonic antigen (CEA), while using synthetic proteins called Affimers for enhanced targeting efficiency.
- - Silica nanoparticles were created and loaded with the photosensitiser Foslip, allowing for effective fluorescence imaging and photodynamic therapy (PDT) when functionalized with anti-CEA Affimers.
- - In experiments with colorectal cancer cell lines and mouse models, these targeted nanoparticles showed significant fluorescence and induced substantial cell death, leading to a notable 4-fold reduction in tumor volume, indicating their potential for effective cancer treatment.
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid malignancies, with a five-year survival of less than 10%. The resistance of the disease and the associated lack of therapeutic response is attributed primarily to its dense, fibrotic stroma, which acts as a barrier to drug perfusion and permits tumour survival and invasion. As clinical trials of chemotherapy (CT), radiotherapy (RT), and targeted agents have not been successful, improving the survival rate in unresectable PDAC remains an urgent clinical need.
View Article and Find Full Text PDFObjectives: Tonsillectomy is a common procedure with significant post-operative pain. This study was designed to compare post-operative pain, returns to a normal diet and normal activity, and duration of regular analgesic use in Coblation and bipolar tonsillectomy patients.
Methods: A total of 137 patients, aged 2-50 years, presenting to a single institution for tonsillectomy or adenotonsillectomy were recruited.