Publications by authors named "N Levine"
Background: Over a century ago, Virchow proposed that cancer represents a chronically inflamed, poorly healing wound. Normal wound healing is represented by a transitory phase of inflammation, followed by a pro-resolution phase, with prostaglandin (PGE2/PGD2)-induced 'lipid class switching' producing inflammation-quenching lipoxins (LXA4, LXB4).
Objective: We explored if lipid dysregulation in colorectal cancers (CRCs) is driven by a failure to resolve inflammation.
Article Synopsis
- The study examined how COVID-19 restrictions influenced the duration of untreated psychosis (DUP) among first-time psychosis patients in Connecticut.
- During the early pandemic, the median DUP significantly dropped from 208 days to 56 days, but later increased to 154 days.
- The time from when psychosis began to starting antipsychotic medication also decreased from 117 days to 35 days, indicating that tighter pandemic restrictions led to quicker treatment responses and could inform future early detection strategies.
Article Synopsis
- Black breast cancer patients have a higher mortality rate than White patients despite advances in early detection and treatment, prompting a study to explore the underlying patient experience disparities.
- The research involved semi-structured interviews and medical record analysis to map the patient journey, identifying key challenges in the four stages of cancer care: diagnosis, surgery, chemotherapy/radiation, and follow-up.
- Both groups faced financial, treatment, and emotional support issues, but Black patients encountered additional hurdles like communication difficulties and delayed diagnoses, underscoring the need for improved provider relationships and support systems.
Article Synopsis
- A drowning definition has been tested using National Syndromic Surveillance Program (NSSP) data to assess its effectiveness in identifying unintentional and undetermined intent drowning (UUID) visits in the Houston region from 2016 to 2022.
- The review revealed that 98% of visits classified as drowning were true positives, with a significant majority (79%) of patients being children under 18.
- The study concludes that syndromic surveillance is a reliable tool for real-time monitoring of drowning incidents in metropolitan areas.
Tripod Fixation of Periacetabular Metastatic Lesions Using the IlluminOss Device.
JBJS Essent Surg Tech
September 2024
Background: Percutaneous tripod fixation of periacetabular lesions is performed at our institution for patients with metastatic bone disease and a need for quick return to systemic therapy. We have begun to use the IlluminOss Photodynamic Bone Stabilization System instead of the metal implants previously described in the literature because of the success of the IlluminOss implant in fixing fragility fractures about the pelvis.
Description: At our institution, the procedure is performed in the interventional radiology suite in order to allow for the use of 3D radiographic imaging and vector guidance systems.