Publications by authors named "N Leslie"
Article Synopsis
- Engineering 3D tissue-like structures is challenging in regenerative medicine, but new self-healing, viscoplastic fluids help with this by allowing easier printing of bioinks.
- Researchers developed gellan gum granular gels that can be used as suspension media for 3D bioprinting, demonstrating effective printing at various temperatures and with low yield stresses.
- The study shows that these gels support cell-laden droplet printing for over a week and can create hydrogel features, highlighting their advantages in biofabrication due to their ease of use, speed, and ability to crosslink.
Article Synopsis
- KMT2C and KMT2D are important enzymes that modify genes, with KMT2C haploinsufficiency recently linked to Kleefstra syndrome 2, a neurodevelopmental disorder (NDD) with unknown clinical details.
- A study involving 98 individuals found that most pathogenic variants in KMT2C span nearly all its exons, making variant interpretation difficult; the study also established a KMT2C DNA methylation signature for better classification of the disorder.
- Key features of KMT2C-related NDD include developmental delays, intellectual disabilities, and distinct facial characteristics, setting it apart from similar conditions like Kleefstra and Kabuki syndromes, indicating the need for its renaming and
Scanning electrochemical microscopy (SECM) is a technique for imaging electrochemical reactions at a surface. The interaction between electrochemical reactions occurring at the sample and scanning electrode tip is quite complicated and requires computer modeling to obtain quantitative information from SECM images. Often, existing computer models must be modified, or a new model must be created from scratch to fit kinetic parameters for different reactive features.
View Article and Find Full Text PDFPTEN is a phosphoinositide lipid phosphatase and an important tumour suppressor protein. PTEN function is reduced or lost in around a third of all human cancers through diverse mechanisms, from gene deletion to changes in the function of proteins which regulate PTEN through direct protein binding. Here we present data from SILAC (Stable Isotope Labelling by Amino acids in Cell culture) proteomic screens to identify proteins which bind to PTEN.
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