Publications by authors named "N Leresche"
Cav3.2 T-type calcium channel is a major molecular actor of neuropathic pain in peripheral sensory neurons, but its involvement at the supraspinal level is almost unknown. In the anterior pretectum (APT), a hub of connectivity of the somatosensory system involved in pain perception, we show that Cav3.
View Article and Find Full Text PDFAbsence seizures in children and teenagers are generally considered relatively benign because of their non-convulsive nature and the large incidence of remittance in early adulthood. Recent studies, however, show that 30% of children with absence seizures are pharmaco-resistant and 60% are affected by severe neuropsychiatric comorbid conditions, including impairments in attention, cognition, memory and mood. In particular, attention deficits can be detected before the epilepsy diagnosis, may persist even when seizures are pharmacologically controlled and are aggravated by valproic acid monotherapy.
View Article and Find Full Text PDFArticle Synopsis
- Initial studies suggested that sensory information from the thalamus is processed in a serial manner through primary sensory cortex layers, particularly from layer 4 to layers 2/3 and 5.
- Recent research indicates that layer 5 neurons can directly process thalamic input, raising questions about the role of layer 2/3 neurons in this sensory processing.
- New experiments show that layer 2/3 pyramidal neurons significantly amplify sensory responses in layer 5 neurons, with the amplification dependent on the speed of the sensory stimulus, suggesting they help regulate sensory input strength in deeper layers.