Publications by authors named "N Lepage"

Objective: Determine current analytical methods and number of cell-free (cf) DNA prenatal screening tests performed for common trisomies.

Methods: The College of American Pathologists 2022-B Noninvasive Prenatal Testing exercise was distributed in December 2022 to 93 participants in 22 countries. Supplemental questions included the number of tests performed in a recent month and the proportion of samples originating outside the United States (US).

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Therapeutic plasma exchange is known to be an extracorporeal treatment procedure with few adverse effects. Anemia in chronically exchanged patients is not a well-recognized adverse effect. Our aim is to find if adult patients develop anemia while undergoing prolonged TPE treatments and to determine the time of onset of anemia.

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Unlabelled: Occupational exposure is associated with elevated morbidity and lower quality of life in patients with chronic obstructive pulmonary disease (COPD). Static hyperinflation is an independent risk factor for all-cause mortality in COPD and for COPD exacerbation. In a multicentre, cross-sectional study (BPROFETIO), we sought to analyse the relationship between static hyperinflation and occupational exposure in patients with COPD with or without occupational exposure.

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Article Synopsis
  • Occupational lung cancer cases are often under-reported and under-compensated, prompting a study to improve detection and compensation through systematic screening of occupational exposures.
  • A self-administered questionnaire was used to gather job history and exposure data from lung cancer patients, with physician assessments leading to specialized consultations for those with potential occupational links.
  • The study found that out of 1251 patients surveyed, a significant portion attended consultations, revealing that many had been exposed to occupational lung carcinogens and subsequently received medical certificates and compensation, highlighting the effectiveness of this screening approach.
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Article Synopsis
  • * In 2020, 56 laboratories reported screening over 1.1 million pregnancies, with a notable drop in testing numbers and a decrease in the number of labs offering these tests compared to eight years earlier.
  • * The significant decline in traditional serum screening (up to 72%) was attributed to the rise of cell-free DNA testing, which saw a substantial increase in usage during the same period.
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