Hypothalamic morphology following ingestion of aspartame or MSG in the neonatal rodent and primate: a preliminary report.

Neonatal mice received oral doses of monosodium glutamate (MSG) at levels of 0.25, 0.5m 1.

Glial changes in the progress of a chemical lesion. An electron microscopic study.

The response of non-neuronal cells in the brain to monosodium glutamate (MSG) was studied in the neonatal mouse brain. Neurons rapidly degenerate in this chemically-induced lesion, and the glia reflect and respond to their early pyknosis and death. Astrocytic glia exhibit the most profound responses in the form of degenerative nuclear and cytoplasmic changes within 15 to 20 minutes after ingestion of MSG.