Publications by authors named "N Lemaitre"
Article Synopsis
- * Researchers aimed to determine the role of antibody-dependent cell-mediated cytotoxicity (ADCC) in avelumab's effectiveness and whether variations in the FcγR3A receptor can predict patient responses.
- * Findings confirmed the presence of FcγR3A+ natural killer (NK) cells in PD-L1-expressing GTN, and that avelumab enhances NK cell activity, further suggesting higher affinity FcγR3A variants may
Article Synopsis
- Predicting spontaneous preterm birth is challenging for public health, especially in asymptomatic women.
- This study aimed to assess whether circulating levels of EG-VEGF can effectively predict preterm birth in women at high risk for placenta-related issues, using data from 200 patients.
- Results showed that women who experienced spontaneous preterm birth had significantly higher EG-VEGF levels at various points in pregnancy, suggesting that these levels could serve as a reliable biomarker for assessing this risk.
The UDP-3--(-3-hydroxyacyl)--acetylglucosamine deacetylase LpxC is an essential enzyme in the biosynthesis of lipid A, the outer membrane anchor of lipopolysaccharide and lipooligosaccharide in Gram-negative bacteria. The development of LpxC-targeting antibiotics toward clinical therapeutics has been hindered by the limited antibiotic profile of reported non-hydroxamate inhibitors and unexpected cardiovascular toxicity observed in certain hydroxamate and non-hydroxamate-based inhibitors. Here, we report the preclinical characterization of a slow, tight-binding LpxC inhibitor, LPC-233, with low picomolar affinity.
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