Publications by authors named "N Leggett"
Article Synopsis
- The systematic review aimed to evaluate digital health interventions for ICU survivors, focusing on five key implementation factors: Reach, Effectiveness, Adoption, Implementation, and Maintenance.
- A comprehensive search across multiple databases led to the inclusion of ten studies, involving 686 participants and demonstrating high acceptability and satisfaction with the interventions.
- Findings showed that intervention adherence rates varied from 46% to 100%, and retention rates for outcome measurements were between 52% and 100%, indicating promising outcomes for patient-reported health after ICU discharge.
Patients and their caregivers navigate multiple transitions of care across the health system as they recover from their critical illness. Current research supports the development of integrated models of care to improve patient outcomes after critical illness. Future research to ensure the development of integrated models across different regions and to understand the optimal mode of delivery of these is required.
View Article and Find Full Text PDFBackground And Aims: Prone positioning is commonly applied to improve gas exchange in mechanically ventilated patients with coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS). Whilst prone positioning is effective, specific complications may arise. We aimed to assess the prevalence of specific complications related to prone positioning in patients mechanically ventilated for COVID-19-related ARDS.
View Article and Find Full Text PDFDespite recent therapeutic advances, metastatic castration-resistant prostate cancer (mCRPC) remains lethal. Chimeric antigen receptor (CAR) T cell therapies have demonstrated durable remissions in hematological malignancies. We report results from a phase 1, first-in-human study of prostate stem cell antigen (PSCA)-directed CAR T cells in men with mCRPC.
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