Publications by authors named "N Lee Wolfe"
Article Synopsis
- Patients with congenital heart disease, particularly those who have undergone the Fontan procedure for single ventricle issues, face a high risk of sudden cardiac events (SCE) and early mortality, highlighting the importance of identifying risk factors.
- In a study involving 3,132 Fontan patients, 3.5% experienced SCE over an average follow-up of 4 years, with 36% of those cases resulting in death.
- Key risk factors for SCE included higher NYHA functional class, history of protein-losing enteropathy or plastic bronchitis, large end-diastolic volume index, and reduced ejection fraction, all of which can help in predicting and preventing such events.
Objective: As metabolic dysfunction-associated steatotic liver disease (MASLD) becomes more prevalent worldwide, it is imperative to create more accurate technologies that make it easy to assess the liver in a point-of-care setting. The aim of this study is to test the performance of a new software tool implemented in Velacur (Sonic Incytes), a liver stiffness and ultrasound attenuation measurement device, on patients with MASLD. This tool employs a deep learning-based method to detect and segment shear waves in the liver tissue for subsequent analysis to improve tissue characterization for patient diagnosis.
View Article and Find Full Text PDFPortal vein hypoplasia is present in patients with biliary atresia at the time of diagnosis.
J Pediatr Gastroenterol Nutr
October 2024
Article Synopsis
- The study investigates patients with biliary atresia (BA) to understand if abnormal portal vein (PV) development leads to severe portal hypertension (HTN) independent of bile obstruction.* -
- A cohort of 47 newborns with cholestasis was examined, revealing that those with BA had smaller PV diameters and larger hepatic artery (HA) diameters compared to other cholestasis cases, but these measurements did not correlate with liver fibrosis.* -
- The results show that 83% of BA patients cleared jaundice, while 66% survived with their native liver by age two; however, 20% experienced serious complications like intestinal bleeding or ascites.*
Background: Guideline-directed heart failure therapy with angiotensin receptor blocker/neprilysin inhibitor (ARNi) and sodium-glucose transporter inhibitors (SGLT2i) has been incrementally beneficial in improving outcomes in heart failure patients.
Objective: Evaluate the feasibility and efficacy of guideline-directed medical therapy (GDMT) in adults congenital heart disease (ACHD) patients.
Methods: In a retrospective cohort study, ACHD patients with either New York Heart Association (NYHA) Class II symptoms or systemic ejection fraction (EF) <45%, optimized on a combination of beta-blocker (BB), ARNi, mineralocorticoid receptor antagonist (MRA) and SGLT2i were evaluated.
The clinical relevance of MOG antibody testing in cerebrospinal fluid.
Ann Clin Transl Neurol
September 2024
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is diagnosed by serum MOG-immunoglobulin G (MOG-IgG) in association with typical demyelination. 111/1127 patients with paired CSF/serum samples were seropositive for MOG-IgG. Only 7/1016 (0.
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