Publications by authors named "N Lean"
Introduction: (STEPS) is a digital application (app) designed to help parents manage behaviour of their children who are referred to mental health services and are waiting for an assessment or treatment. STEPS is currently being evaluated in the Online Parent Training for the Initial Management of Attention-Deficit/Hyperactivity Disorder randomised controlled trial. Alongside the examination of STEPS' clinical and cost-effectiveness, we are conducting a process evaluation to better understand the contextual factors that may influence study outcomes.
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- The study evaluated a prototype dynamic laryngoplasty system (DLPS) on 7 healthy Standardbred horses to assess its feasibility for treating laryngeal issues.
- A standing surgical procedure induced complete laryngeal hemiplegia, and the DLPS showed effective delivery with no complications during the trial.
- Results indicated that while the DLPS could improve airway function 7 days post-surgery, long-term effects (1 month) were limited due to potential fibrosis around the implant.
Objective: To describe left recurrent laryngeal neurectomy (LRLn) performed under standing sedation and evaluate the effect of LRLn on upper respiratory tract function using a high-speed treadmill test (HST). We hypothesized that (1) unilateral LRLn could be performed in standing horses, resulting in ipsilateral arytenoid cartilage collapse (ACC); and (2) HST after LRLn would be associated with alterations in upper respiratory function consistent with dynamic ACC.
Animals: 6 Thoroughbred horses.
Background: The Structured E-Parenting Support (STEPS) app provides support for parents of children with elevated hyperactivity, impulsivity, inattention, and conduct problems who are awaiting clinical assessment. STEPS will be evaluated in a randomized controlled trial (RCT) within the Online Parent Training for the Initial Management of ADHD Referrals (OPTIMA) research program in the United Kingdom. Phase 1 of the OPTIMA tested the feasibility of participants' recruitment and the app's usability.
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- The study examines differences between domestic and feral horses in terms of the left recurrent laryngeal nerve (Lrln) and left cricoarytenoideus dorsalis (LCAD) muscle, focusing on possible implications for recurrent laryngeal neuropathy (RLN).
- Sixteen horses (8 domestic and 8 feral) were analyzed using histological and immunohistochemical methods after being harvested at an abattoir, revealing some differences in muscle fiber types and regeneration patterns.
- Results indicated that domestic horses showed more signs of nerve regeneration consistent with RLN and had a higher percentage of type IIX muscle fibers compared to feral horses, prompting further investigation to determine the significance of these findings.