Publications by authors named "N Le Roux"
Despite much literature on operations research applied to various healthcare problems, impactful implementation in public healthcare is limited, which often results in allocative inefficiency. This article uses a mobile clinic routing and scheduling problem in the Witzenberg region of South Africa as a case study to demonstrate the improvement of implementation success through cross-disciplinary collaboration, and also to propose a new three-stage approach for modelling a mobile clinic problem that incorporates continuity of care, fairness, and minimisation of distance travelled. Mobile clinics are used in many countries to improve access to healthcare for rural communities.
View Article and Find Full Text PDFObjective: To examine the course of interstitial lung disease associated with rheumatoid arthritis (RA-ILD) in France on treatment with Janus kinase inhibitors (JAKis) using the MAJIK-SFR registry.
Methods: Prospective national multicentre observational study identifying patients with RA-ILD from the MAJIK-SFR registry. Pulmonary assessment data were collected at JAKi initiation and follow-up visits (6 months, 12 months and a median of 21 months postinclusion), including chest high-resolution CT (HRCT), pulmonary function tests (forced vital capacity (FVC) and diffusing capacity of the lungs for carbon monoxide (DLCO)), acute exacerbations of ILD, respiratory infections and lung cancers.
Most teleost fishes exhibit a biphasic life history with a larval oceanic phase that is transformed into morphologically and physiologically different demersal, benthic, or pelagic juveniles. This process of transformation is characterized by a myriad of hormone-induced changes, during the often abrupt transition between larval and juvenile phases called metamorphosis. Thyroid hormones (TH) are known to be instrumental in triggering and coordinating this transformation but other hormonal systems such as corticoids, might be also involved as it is the case in amphibians.
View Article and Find Full Text PDFThroughout the world, anthropogenic pressure on natural ecosystems is intensifying, notably through urbanisation, economic development, and tourism. Coral reefs have become exposed to stressors related to tourism. To reveal the impact of human activities on fish communities, we used COVID-19-related social restrictions in 2021.
View Article and Find Full Text PDFArticle Synopsis
- Fontaine progeroid syndrome (FPS) is a newly identified genetic disorder linked to mutations in the SLC25A24 gene, resulting in severe physical abnormalities such as craniosynostosis and growth restrictions.
- The first documented prenatal cases during the second trimester show different phenotypic features, including encephalocele and nephromegaly, while lacking some typical signs of FPS seen after birth.
- The study highlights the importance of genetic testing methods like exome/genome sequencing for diagnosing rare syndromes, suggesting that FPS may involve a novel inheritance pattern.